Selective extraction of cordycepin from Cordyceps militaris - optimisation, kinetics and equilibrium studies

被引：4
|
作者：
Sornchaithawatwong, Chayanid [1 ]
Kunthakudee, Naphaphan [2 ]
Sunsandee, Niti [3 ]
Ramakul, Prakorn [2 ]
机构：
[1] Srinakharinwirot Univ, Fac Pharm, Dept Pharmaceut Chem, Nakhonnayok, Thailand
[2] Silpakorn Univ, Fac Engn & Ind Technol, Dept Chem Engn, Nakhon Pathom 73000, Thailand
[3] Chulalongkorn Univ, Fac Engn, Dept Chem Engn, Bangkok, Thailand
来源：
INDIAN CHEMICAL ENGINEER | 2022年 / 64卷 / 01期
关键词：
Cordycepin; Cordyceps militaris; extraction; RP-HPLC; POLYSACCHARIDE; IDENTIFICATION; PURIFICATION; ANTITUMOR; SINENSIS;
D O I：
10.1080/00194506.2020.1776163
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Cordycepin was separated successfully from Cordyceps militaris using extraction with a mixture of ethanol and water. Optimum temperature, composition of ethanol in water, solvent/solid ratio and pH of solvent were determined by a central composite design (CCD) with respect to extraction yield. The highest yield for cordycepin (96%) was predicted by the regression model and validated by comparison with the experimental results, showing good agreement. The RP-HPLC method was applied to analyse cordycepin from Cordyceps militaris extracts, and 100% purity of cordycepin was achieved. The extraction characteristics were investigated in terms of equilibrium and kinetics. The second-order kinetics correlates well with the experimental data.
引用
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页码：1 / 13
页数：13
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