Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice

被引：24

作者：

Ahmad, S ^{[1
]}

Anderson, WL ^{[1
]}

Kitchin, KT ^{[1
]}

机构：

[1] US EPA, Natl Hlth & Environm Effects Res Lab, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA

来源：

CANCER LETTERS | 1999年 / 139卷 / 02期

关键词：

dimethylarsinic acid; DNA damage; oxidative stress; B6C3F1; mice;

D O I：

10.1016/S0304-3835(99)00022-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Significant (P < 0.05) decreases in liver GSH and GSSG contents (15-37%) were observed. Some evidence of DMA-induced hepatic DNA damage (at the P < 0.10 level only) was observed. Pulmonary and hepatic ODC activities were reduced (19-59%) by DMA treatment. Overall, these biochemical studies show that mice are much less responsive to DMA than rats. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：129 / 135

页数：7

共 45 条

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