From membrane tension to channel gating: A principal energy transfer mechanism for mechanosensitive channels

被引：18
|
作者：
Zhang, Xuejun C. [1 ]
Liu, Zhenfeng [1 ]
Li, Jie [1 ]
机构：
[1] Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
来源：
PROTEIN SCIENCE | 2016年 / 25卷 / 11期
基金：
中国国家自然科学基金;
关键词：
mechanosensitive channels; gating mechanism; lipid-protein interaction; membrane tension sensing; osmoregulation; ESCHERICHIA-COLI; ION-CHANNEL; LARGE-CONDUCTANCE; BILAYER THICKNESS; CRYSTAL-STRUCTURE; LIPID-BILAYERS; SINGLE RESIDUE; MSCL; PRESSURE; PROTEIN;
D O I：
10.1002/pro.3017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mechanosensitive (MS) channels are evolutionarily conserved membrane proteins that play essential roles in multiple cellular processes, including sensing mechanical forces and regulating osmotic pressure. Bacterial MscL and MscS are two prototypes of MS channels. Numerous structural studies, in combination with biochemical and cellular data, provide valuable insights into the mechanism of energy transfer from membrane tension to gating of the channel. We discuss these data in a unified two-state model of thermodynamics. In addition, we propose a lipid diffusion-mediated mechanism to explain the adaptation phenomenon of MscS.
引用
收藏
页码：1954 / 1964
页数：11
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