The adipose tissue and the involvement of the renin-angiotensin-aldosterone system in cardiometabolic syndrome

被引：13

作者：

Borghi, F. ^{[1
]}

Seva-Pessoa, B. ^{[2
]}

Grassi-Kassisse, D. M. ^{[1
]}

机构：

[1] Univ Campinas UNICAMP, Dept Struct & Funct Biol, LABEEST Lab Stress Study, Inst Biol, BR-13083862 Campinas, SP, Brazil

[2] Univ Fed Sao Paulo, Div Nephrol, Dept Med, Lab Kidney & Hormones,Escola Paulista Med, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil

来源：

CELL AND TISSUE RESEARCH | 2016年 / 366卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Adipose tissue; Angiotensin; Cardiometabolic syndrome; Renin-angiotensin-aldosterone system; Adiposity; MINERALOCORTICOID RECEPTOR; LIPID-METABOLISM; NITRIC-OXIDE; INHIBITION; HYPERTENSION; ALAMANDINE; ADIPOCYTES; EXPRESSION; AUTOCRINE; BIOLOGY;

D O I：

10.1007/s00441-016-2515-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiometabolic diseases are linked to a cluster of modifiable factors, including risk factors closely related to central adiposity. Chronic renin-angiotensin-aldosterone system (RAAS) activation has far-reaching effects on cardiometabolic risk and is a substantial contributor to this clinical condition. RAAS components are locally expressed in the vessels and adipose tissue. This review appoints RAAS, through the classical and the alternative view, as the main mediator of the cross-talk in cardiometabolic syndrome.

引用

页码：543 / 548

页数：6

共 59 条

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