Cell-growth and migration inhibition of human mesothelioma cells induced by 3-O-Methylfunicone from Penicillium pinophilum and cisplatin

被引：15

作者：

Buommino, Elisabetta ^{[1
]}

De Filippis, Anna ^{[1
]}

Nicoletti, Rosario ^{[2
]}

Menegozzo, Massimo ^{[3
]}

Menegozzo, Simona ^{[3
]}

Ciavatta, Maria Letizia ^{[4
]}

Rizzo, Antonietta ^{[1
]}

Brancato, Virginia ^{[1
]}

Tufano, Maria Antonietta ^{[1
]}

Donnarumma, Giovanna ^{[1
]}

机构：

[1] Univ Naples 2, Sect Microbiol & Clin Microbiol, Dept Expt Med, I-80128 Naples, Italy

[2] Council Res & Experimentat Agr, CAT Res Unit, Scafati, Italy

[3] SUN, Sect Job Med, Dept Expt Med, Naples, Italy

[4] Inst Biomol Chem ICB CNR, Pozzuoli, Italy

来源：

INVESTIGATIONAL NEW DRUGS | 2012年 / 30卷 / 04期

关键词：

Mesothelioma; 3-O-methylfunicone; Cisplatin; Integrins; Metalloproteinase; Migration; MALIGNANT PLEURAL MESOTHELIOMA; MOLECULAR-BIOLOGY; METABOLITE; APOPTOSIS; CHEMOTHERAPY; EXPRESSION; MOTILITY;

D O I：

10.1007/s10637-011-9698-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant pleural mesothelioma is a fatal malignancy linked to asbestos exposure. The main challenge for mesothelioma treatment is to go beyond the drug resistance, in particular against cisplatin (CDDP), one of the most used chemotherapeutic drug. 3-O-methylfunicone (OMF) is a metabolite produced by the fungus Penicillium pinophilum; its antiproliferative properties have been previously studied in vitro. Particularly, OMF is able to inhibit mesothelioma cell motility. To improve the effects of CDDP by-passing the resistance of mesothelioma cells to this drug, in the present study we investigated the combined treatment of OMF with CDDP respectively in an established mesothelioma cell line (NCI) and primary mesothelioma cells (Mest). As compared to the effect of single treatments, the combination of OMF and CDDP resulted in a stronger inhibition of NCI and Mest cell proliferation. OMF combination with CDDP was also able to affect the migratory ability of NCI and Mest cells by down-regulating alpha v and beta 5 expression and reducing metalloproteinase 2 (MMP-2) production. In addition, this association was effective in modulating VEGF gene expression. This finding highlights the possibility to use OMF and CDDP together to regulate angiogenesis and tumour progression in mesothelioma.

引用

页码：1343 / 1351

页数：9

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