Differentiation and enrichment of cardiomyocytes from human pluripotent stem cells

被引：27

作者：

Xu, Chunhui ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2012年 / 52卷 / 06期

关键词：

Cardiomyocytes; Differentiation; Growth factors; Stem cells; Small molecules; TERM SELF-RENEWAL; CARDIAC DIFFERENTIATION; VENTRICULAR CARDIOMYOCYTES; FUNCTIONAL-PROPERTIES; DEFINED MEDIUM; MOUSE; INDUCTION; CULTURE; HEART; CARDIOMYOGENESIS;

D O I：

10.1016/j.yjmcc.2012.03.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human cardiomyocytes derived from pluripotent stem cells hold great promise for cardiac cell therapy, disease modeling, drug discovery, and the study of developmental biology. Reaching these potentials fully requires the development of methods that enable efficient and robust generation of cardiomyocytes with expected characteristics. This review summarizes and discusses up-to-date methods that have been used to derive and enrich human cardiomyocytes from pluripotent stem cells, provides a brief overview of in vitro and in vivo characterization of these cardiomyocytes, and considers future advancement needed to further harness the power of these cells. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1203 / 1212

页数：10

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