RhoE is required for contact inhibition and negatively regulates tumor initiation and progression

被引：13

作者：

Hernandez-Sanchez, Marta ^{[1
,5
]}

Poch, Enric ^{[1
]}

Guasch, Rosa M. ^{[2
]}

Ortega, Joaquin ^{[3
]}

Lopez-Almela, Inmaculada ^{[1
]}

Palmero, Ignacio ^{[4
]}

Perez-Roger, Ignacio ^{[1
]}

机构：

[1] Univ CEU Cardenal Herrera, Fac Ciencias Salud, Dept Ciencias Biomed, Moncada, Spain

[2] Rho Signaling Neuropathol, Ctr Invest Principe Felipe, Valencia, Spain

[3] Univ CEU Cardenal Herrera, Fac Vet, Dept PASACTA, Moncada, Spain

[4] CSIC UAM, Inst Invest Biomed Alberto Sols, Madrid, Spain

[5] Univ Autonoma Barcelona, Dept Biol Cellular Fisiol & Immunol, Cerdanyola Del Valles, Spain

来源：

ONCOTARGET | 2015年 / 6卷 / 19期

关键词：

contact inhibition; metastasis; RhoE; tumor suppression; p27(Kip1); CANCER-CELL MOTILITY; ROCK-I; PROSTATE-CANCER; P27; GROWTH; PHOSPHORYLATION; IDENTIFICATION; PROLIFERATION; METASTASIS; EXPRESSION;

D O I：

10.18632/oncotarget.4127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RhoE is a small GTPase involved in the regulation of actin cytoskeleton dynamics, cell cycle and apoptosis. The role of RhoE in cancer is currently controversial, with reports of both oncogenic and tumor-suppressive functions for RhoE. Using RhoE-deficient mice, we show here that the absence of RhoE blunts contact-inhibition of growth by inhibiting p27(Kip1) nuclear translocation and cooperates in oncogenic transformation of mouse primary fibroblasts. Heterozygous RhoE(+/gt) mice are more susceptible to chemically induced skin tumors and RhoE knock-down results in increased metastatic potential of cancer cells. These results indicate that RhoE plays a role in suppressing tumor initiation and progression.

引用

页码：17479 / 17490

页数：12

共 52 条

[11] RhoE Promotes Metastasis in Gastric Cancer through a Mechanism Dependent on Enhanced Expression of CXCR4 [J].

Feng, Bin ;

Li, Kai ;

Zhong, Haixing ;

Ren, Gui ;

Wang, Hefei ;

Shang, Yulong ;

Bai, Ming ;

Liang, Jie ;

Wang, Xin ;

Fan, Daiming .

PLOS ONE, 2013, 8 (11)

[12]

Foster R, 1996, MOL CELL BIOL, V16, P2689

[13] MicroRNA-200b Stimulates Tumour Growth in TGFBR2-Null Colorectal Cancers by Negatively Regulating p27/kip1 [J].

Fu, Yuxuan ;

Liu, Xianghua ;

Zhou, Ningtian ;

Du, Lijian ;

Sun, Yu ;

Zhang, Xiang ;

Ge, Yingbin .

JOURNAL OF CELLULAR PHYSIOLOGY, 2014, 229 (06) :772-782

[14] Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion [J].

Grise, Florence ;

Sena, Sandra ;

Bidaud-Meynard, Aurelien ;

Baud, Jessica ;

Hiriart, Jean-Baptiste ;

Makki, Kassem ;

Dugot-Senant, Nathalie ;

Staedel, Cathy ;

Bioulac-Sage, Paulette ;

Zucman-Rossi, Jessica ;

Rosenbaum, Jean ;

Moreau, Violaine .

HEPATOLOGY, 2012, 55 (06) :1766-1775

[15] RhoE regulates actin cytoskeleton organization and cell migration [J].

Guasch, RM ;

Scambler, P ;

Jones, GE ;

Ridley, AJ .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (08) :4761-4771

[16] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[17]

Hayflick L, 1973, Tissue Culture Methods and Applications

[18] Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6 [J].

Hidalgo-Carcedo, Cristina ;

Hooper, Steven ;

Chaudhry, Shahid I. ;

Williamson, Peter ;

Harrington, Kevin ;

Leitinger, Birgit ;

Sahai, Erik .

NATURE CELL BIOLOGY, 2011, 13 (01) :49-U123

[19] Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export [J].

Ishida, N ;

Hara, T ;

Kamura, T ;

Yoshida, M ;

Nakayama, K ;

Nakayama, KI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (17) :14355-14358

[20] Multistep skin cancer in mice as a model to study the evolution of cancer cells [J].

Kemp, CJ .

SEMINARS IN CANCER BIOLOGY, 2005, 15 (06) :460-473

← 1 2 3 4 5 6 →