RhoE is required for contact inhibition and negatively regulates tumor initiation and progression

被引：13

作者：

Hernandez-Sanchez, Marta ^{[1
,5
]}

Poch, Enric ^{[1
]}

Guasch, Rosa M. ^{[2
]}

Ortega, Joaquin ^{[3
]}

Lopez-Almela, Inmaculada ^{[1
]}

Palmero, Ignacio ^{[4
]}

Perez-Roger, Ignacio ^{[1
]}

机构：

[1] Univ CEU Cardenal Herrera, Fac Ciencias Salud, Dept Ciencias Biomed, Moncada, Spain

[2] Rho Signaling Neuropathol, Ctr Invest Principe Felipe, Valencia, Spain

[3] Univ CEU Cardenal Herrera, Fac Vet, Dept PASACTA, Moncada, Spain

[4] CSIC UAM, Inst Invest Biomed Alberto Sols, Madrid, Spain

[5] Univ Autonoma Barcelona, Dept Biol Cellular Fisiol & Immunol, Cerdanyola Del Valles, Spain

来源：

ONCOTARGET | 2015年 / 6卷 / 19期

关键词：

contact inhibition; metastasis; RhoE; tumor suppression; p27(Kip1); CANCER-CELL MOTILITY; ROCK-I; PROSTATE-CANCER; P27; GROWTH; PHOSPHORYLATION; IDENTIFICATION; PROLIFERATION; METASTASIS; EXPRESSION;

D O I：

10.18632/oncotarget.4127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RhoE is a small GTPase involved in the regulation of actin cytoskeleton dynamics, cell cycle and apoptosis. The role of RhoE in cancer is currently controversial, with reports of both oncogenic and tumor-suppressive functions for RhoE. Using RhoE-deficient mice, we show here that the absence of RhoE blunts contact-inhibition of growth by inhibiting p27(Kip1) nuclear translocation and cooperates in oncogenic transformation of mouse primary fibroblasts. Heterozygous RhoE(+/gt) mice are more susceptible to chemically induced skin tumors and RhoE knock-down results in increased metastatic potential of cancer cells. These results indicate that RhoE plays a role in suppressing tumor initiation and progression.

引用

页码：17479 / 17490

页数：12

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