Introduction: In experimental models of West Nile virus (WNV) infection, animals develop chronic kidney infection with histopathological changes in the kidney up to 8-months post-infection. However, the long term pathologic effects of acute infection in humans are largely unknown. The purpose of this study was to assess renal outcomes following WNV infection, specifically the development of chronic kidney disease (CKD). Methods: In a cohort of 139 study participants with a previous diagnosis of WNV infection, we investigated the prevalence of CKD using the Kidney Disease Outcomes Quality Initiative (KDOQI) criteria based on the Modification of Diet in Renal Disease (MDRD) formula and urinary abnormalities, and assessed various risk factors and biomarkers. Results: Study participants were primarily male (60%) and non-Hispanic white (86%) with a mean age of 57 years. Most (83%) were four to nine years post-infection at the time of this study. Based on the KDOQI definition, 40% of participants had evidence of CKD, with 10% having Stage III or greater and 30% having Stage I-II. By urinary dipstick testing, 26% of patients had proteinuria and 23% had hematuria. Plasma NGAL levels were elevated in 14% of participants while MCP-1 levels were increased in 12%. Over 1.5 years, the average change in eGFR was -3.71 mL/min/1.73 m(2). Only a history of Neuroinvasive WNV disease was independently associated with CKD following multivariate analysis. Discussion: We found a high prevalence of CKD after long term follow-up in a cohort of participants previously infected with WNV. The majority of those with CKD are in Stage I-II indicating early stages of renal disease. Traditional risk factors were not associated with the presence of CKD in this population. Therefore, clinicians should regularly evaluate all patients with a history of WNV for evidence of CKD.
机构:
Univ Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, England
Altemtam, Nagi
论文数: 引用数:
h-index:
机构:
Russell, Jean
El Nahas, Meguid
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, England
机构:
Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Baty, Steven A.
Gibney, Katherine B.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Gibney, Katherine B.
Staples, J. Erin
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Staples, J. Erin
Patterson, Andrean Bunko
论文数: 0引用数: 0
h-index: 0
机构:
Maricopa Cty Dept Publ Hlth, Phoenix, AZ USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Patterson, Andrean Bunko
Levy, Craig
论文数: 0引用数: 0
h-index: 0
机构:
Arizona Dept Hlth Serv, Phoenix, AZ 85007 USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Levy, Craig
Lehman, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Lehman, Jennifer
Wadleigh, Tricia
论文数: 0引用数: 0
h-index: 0
机构:
Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA
Ctr Dis Control & Prevent, Off State Tribal Local & Territorial Support, Atlanta, GA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Wadleigh, Tricia
Feld, Jamie
论文数: 0引用数: 0
h-index: 0
机构:
Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA
Ctr Dis Control & Prevent, Off State Tribal Local & Territorial Support, Atlanta, GA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Feld, Jamie
Lanciotti, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Lanciotti, Robert
Nugent, C. Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Gen Probe Inc, San Diego, CA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Nugent, C. Thomas
Fischer, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Clark, William F.
Macnab, Jennifer J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Macnab, Jennifer J.
Sontrop, Jessica M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Sontrop, Jessica M.
Jain, Arsh K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Jain, Arsh K.
Moist, Louise
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Moist, Louise
Salvadori, Marina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Salvadori, Marina
Suri, Rita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Suri, Rita
Garg, Amit X.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Garg, Amit X.
[J].
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,
2011,
22
(09):
: 1729
-
1736
机构:
Univ Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, England
Altemtam, Nagi
论文数: 引用数:
h-index:
机构:
Russell, Jean
El Nahas, Meguid
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sheffield Kidney Inst, Acad Nephrol Unit, Sheffield, S Yorkshire, England
机构:
Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Baty, Steven A.
Gibney, Katherine B.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Gibney, Katherine B.
Staples, J. Erin
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Staples, J. Erin
Patterson, Andrean Bunko
论文数: 0引用数: 0
h-index: 0
机构:
Maricopa Cty Dept Publ Hlth, Phoenix, AZ USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Patterson, Andrean Bunko
Levy, Craig
论文数: 0引用数: 0
h-index: 0
机构:
Arizona Dept Hlth Serv, Phoenix, AZ 85007 USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Levy, Craig
Lehman, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Lehman, Jennifer
Wadleigh, Tricia
论文数: 0引用数: 0
h-index: 0
机构:
Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA
Ctr Dis Control & Prevent, Off State Tribal Local & Territorial Support, Atlanta, GA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Wadleigh, Tricia
Feld, Jamie
论文数: 0引用数: 0
h-index: 0
机构:
Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA
Ctr Dis Control & Prevent, Off State Tribal Local & Territorial Support, Atlanta, GA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Feld, Jamie
Lanciotti, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Lanciotti, Robert
Nugent, C. Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Gen Probe Inc, San Diego, CA USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
Nugent, C. Thomas
Fischer, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO USAArizona Dept Hlth Serv, Phoenix, AZ 85007 USA
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Clark, William F.
Macnab, Jennifer J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Macnab, Jennifer J.
Sontrop, Jessica M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Sontrop, Jessica M.
Jain, Arsh K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Jain, Arsh K.
Moist, Louise
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Moist, Louise
Salvadori, Marina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Salvadori, Marina
Suri, Rita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Suri, Rita
Garg, Amit X.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
London Hlth Sci Ctr, London Kidney Clin Res Unit, London, ON, CanadaUniv Western Ontario, Dept Med, Div Nephrol, London, ON, Canada
Garg, Amit X.
[J].
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,
2011,
22
(09):
: 1729
-
1736