Diagnostic imaging of Alzheimer's disease with copper and technetium complexes

被引：63
作者：
Hickey, James L.
Donnelly, Paul S. [1 ]
机构：
[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
来源：
COORDINATION CHEMISTRY REVIEWS | 2012年 / 256卷 / 19-20期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
Copper complexes; Technetium complexes; Alzheimer's disease; Radiopharmaceuticals; Brain imaging; Diagnosis of Alzheimer's disease; BETA-AMYLOID PLAQUES; POSITRON-EMISSION-TOMOGRAPHY; A-BETA; BIS(THIOSEMICARBAZONE) COMPLEXES; HYPOXIA SELECTIVITY; POTENTIAL PROBES; IN-VITRO; TC-99M-MAMA-CHRYSAMINE G; NEUROFIBRILLARY TANGLES; BENZOFURAN DERIVATIVES;
D O I：
10.1016/j.ccr.2012.03.035
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The most common form of dementia is Alzheimer's disease, a progressive neurodegenerative disease that leads to synaptic failure and neuronal death. This review discusses the development of copper and technetium coordination complexes designed as radiopharmaceuticals to assist in the diagnosis of Alzheimer's disease using positron emission tomography or single photon emission computed tomography. Technetium complexes used to image regional brain perfusion are discussed as well as copper and technetium complexes specifically designed to bind to amyloid-p plaques that are associated with the onset of symptoms of the disease. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：2367 / 2380
页数：14
相关论文
共 132 条
[71]   A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-β plaques [J].
Lim, SinChun ;
Paterson, Brett M. ;
Fodero-Tavoletti, Michelle T. ;
O'Keefe, Graeme J. ;
Cappai, Roberto ;
Barnham, Kevin J. ;
Villemagne, Victor L. ;
Donnelly, Paul S. .
CHEMICAL COMMUNICATIONS, 2010, 46 (30) :5437-5439
[72]   Synthesis and β-amyloid binding properties of rhenium 2-phenylbenzothiazoles [J].
Lin, Kuo-Shyan ;
Debnath, Manik L. ;
Mathis, Chester A. ;
Klunk, William E. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (08) :2258-2262
[73]   The role of coordination chemistry in the development of target-specific radiopharmaceuticals [J].
Liu, S .
CHEMICAL SOCIETY REVIEWS, 2004, 33 (07) :445-461
[74]   99mTc-Labeled small peptides as diagnostic radiopharmaceuticals [J].
Liu, S ;
Edwards, DS .
CHEMICAL REVIEWS, 1999, 99 (09) :2235-2268
[75]   PIB is a non-specific imaging marker of amyloid-beta (Aβ) peptide-related cerebral amyloidosis [J].
Lockhart, A. ;
Lamb, J. R. ;
Osredkar, T. ;
Sue, L. I. ;
Joyce, J. N. ;
Ye, L. ;
Libri, V. ;
Leppert, D. ;
Beach, T. G. .
BRAIN, 2007, 130 :2607-2615
[76]   Copper, iron and zinc in Alzheimer's disease senile plaques [J].
Lovell, MA ;
Robertson, JD ;
Teesdale, WJ ;
Campbell, JL ;
Markesbery, WR .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 158 (01) :47-52
[77]  
Ma MT, 2011, CURR TOP MED CHEM, V11, P500
[78]   Alzheimer's disease - A new take on tau [J].
Marx, Jean .
SCIENCE, 2007, 316 (5830) :1416-1417
[79]   AMYLOID PLAQUE CORE PROTEIN IN ALZHEIMER-DISEASE AND DOWN SYNDROME [J].
MASTERS, CL ;
SIMMS, G ;
WEINMAN, NA ;
MULTHAUP, G ;
MCDONALD, BL ;
BEYREUTHER, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) :4245-4249
[80]   Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics [J].
Masters, Colin L. ;
Cappai, Roberto ;
Barnham, Kevin J. ;
Villemagne, Victor L. .
JOURNAL OF NEUROCHEMISTRY, 2006, 97 (06) :1700-1725
3456789101112