Diagnostic imaging of Alzheimer's disease with copper and technetium complexes

被引：63

作者：

Hickey, James L.

Donnelly, Paul S. ^{[1
]}

机构：

[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

来源：

COORDINATION CHEMISTRY REVIEWS | 2012年 / 256卷 / 19-20期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Copper complexes; Technetium complexes; Alzheimer's disease; Radiopharmaceuticals; Brain imaging; Diagnosis of Alzheimer's disease; BETA-AMYLOID PLAQUES; POSITRON-EMISSION-TOMOGRAPHY; A-BETA; BIS(THIOSEMICARBAZONE) COMPLEXES; HYPOXIA SELECTIVITY; POTENTIAL PROBES; IN-VITRO; TC-99M-MAMA-CHRYSAMINE G; NEUROFIBRILLARY TANGLES; BENZOFURAN DERIVATIVES;

D O I：

10.1016/j.ccr.2012.03.035

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The most common form of dementia is Alzheimer's disease, a progressive neurodegenerative disease that leads to synaptic failure and neuronal death. This review discusses the development of copper and technetium coordination complexes designed as radiopharmaceuticals to assist in the diagnosis of Alzheimer's disease using positron emission tomography or single photon emission computed tomography. Technetium complexes used to image regional brain perfusion are discussed as well as copper and technetium complexes specifically designed to bind to amyloid-p plaques that are associated with the onset of symptoms of the disease. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：2367 / 2380

页数：14

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