Is Parkinson's disease a chronic low-grade inflammatory bowel disease?

被引：68

作者：

Rolli-Derkinderen, Malvyne ^{[1
,2
,3
]}

Leclair-Visonneau, Laurene ^{[1
,2
,4
]}

Bourreille, Arnaud ^{[1
,2
,3
]}

Coron, Emmanuel ^{[1
,2
,3
]}

Neunlist, Michel ^{[1
,2
,3
]}

Derkinderen, Pascal ^{[1
,2
,5
]}

机构：

[1] Inserm, U1235, 1 Rue Gaston Veil, F-44035 Nantes, France

[2] Univ Nantes, F-44093 Nantes, France

[3] CHU Nantes, Inst Malad Appareil Digestif, F-44093 Nantes, France

[4] CHU Nantes, Dept Physiol, F-44093 Nantes, France

[5] CHU Nantes, Dept Neurol, F-44093 Nantes, France

来源：

JOURNAL OF NEUROLOGY | 2020年 / 267卷 / 08期

关键词：

Parkinson's disease; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Enteric nervous system; LRRK2; CROHNS-DISEASE; ULCERATIVE-COLITIS; ALPHA-SYNUCLEIN; APPENDECTOMY; RISK; DYSFUNCTION; PATHOLOGY; VAGOTOMY; MODEL;

D O I：

10.1007/s00415-019-09321-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

While the pathogenesis of Parkinson's disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The inflammatory process in Parkinson's disease is, however, not limited to the brain but also involves the gastrointestinal tract. High amounts of cytokines and inflammatory markers are found in the colon of Parkinson's disease patients and there is now strong epidemiological and genetical evidence linking Parkinson's disease to inflammatory bowel diseases. Recent findings obtained in both experimental inflammatory bowel diseases and Parkinson's disease further support a bidirectional link between gastrointestinal inflammation and brain neurodegeneration. Altogether, these observations suggest a role for gastrointestinal inflammation in the initiation and progression of Parkinson's disease.

引用

页码：2207 / 2213

页数：7

共 50 条

[1] THE CENTRAL ORGANIZATION OF THE VAGUS NERVE INNERVATING THE COLON OF THE RAT [J].