Steroidal Glycosides from the Rhizomes of Anemarrhena asphodeloides and Their Antiplatelet Aggregation Activity

被引：55

作者：

Kang, Li-ping ^{[2
]}

Zhang, Jie

Cong, Yue

Li, Bin

Xiong, Cheng-qi

Zhao, Yang

Tan, Da-wei

Yu, He-shui ^{[2
]}

Yu, Zu-yin

Cong, Yu-wen

Liu, Chao

Ma, Bai-ping ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Dept Biotechnol, Beijing 100850, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 06期

关键词：

Anemarrhena asphodeloides; Liliaceae; timosaponins J; K; and L; steroidal glycosides; antiplatelet aggregation activity; SAPONINS;

D O I：

10.1055/s-0031-1298223

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new steroidal glycosides, timosaponin J (1), timosaponin K (2), (25S)-karatavioside C (5), timosaponin L (6), and (25S)-officinalisnin-I (8), together with eight known steroidal saponins, timosaponin E-1 (3), purpureagitosid (4), timosaponin BII (7), timosaponin B III (9), anemarrhenasaponin I (10), anemarrhenasaponin III (11), anemarrhenasaponin A(2) (12), and timosaponin A III (13), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were elucidated on the basis of spectroscopic and chemical evidence. The aglycones of compounds 1 and 2 are new aglycones. Compounds 1-13 were evaluated for their platelet aggregation activities, and compound 13 exhibited the strongest inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation.

引用

页码：611 / 616

页数：6

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