The Molecular Pathology of Appendiceal Neoplasms

被引:1
作者
Leeming, Amy
Worrall, David
Arends, Mark Johan
机构
[1] Univ Edinburgh, Div Pathol, Edinburgh, Midlothian, Scotland
[2] Western Gen Hosp, Pathol Dept, Edinburgh, Midlothian, Scotland
来源
AJSP-REVIEWS AND REPORTS | 2019年 / 24卷 / 03期
关键词
appendiceal neoplasms; hyperplastic polyps; molecular pathology; serrated lesions; GOBLET CELL CARCINOIDS; SYNCHRONOUS MUCINOUS TUMORS; PSEUDOMYXOMA PERITONEI; LOW-GRADE; MICROSATELLITE INSTABILITY; SERRATED POLYPS; KRAS MUTATIONS; BRAF-MUTATIONS; RAS; GNAS;
D O I
10.1097/PCR.0000000000000304
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We review the molecular pathological changes of appendiceal neoplasms, in part using the consensus terminology agreed by the Peritoneal Surface Oncology Group International (Am J Surg Pathol 2016;40 (1):14-26; Histopathology 2017;71(6):847-858), with appendiceal neoplasms subcategorized as hyperplastic polyps and serrated lesions (with and without dysplasia), appendiceal mucinous neoplasms (low and high grade), adenocarcinoma, goblet cell tumors, and neuroendocrine neoplasms.
引用
收藏
页码:94 / 97
页数:4
相关论文
共 34 条
[1]   RAS signaling in colorectal carcinomas through alterations of RAS, RAF, NF1, and/or RASSF1A [J].
Ahlquist, Terje ;
Bottillo, Irene ;
Danielsen, Stine A. ;
Meling, Gunn I. ;
Rognum, Torleiv O. ;
Lind, Guro E. ;
Dallapiccola, Bruno ;
Lothe, Ragnhild A. .
NEOPLASIA, 2008, 10 (07) :680-U3
[2]   Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis [J].
Borazanci, Erkut ;
Millis, Sherri Z. ;
Kimbrough, Jeffery ;
Doll, Nancy ;
Von Hoff, Daniel ;
Ramanathan, Ramesh K. .
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2017, 8 (01) :164-172
[3]   Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma [J].
Carr, N. J. ;
Mahajan, H. ;
Tan, K. L. ;
Hawkins, N. J. ;
Ward, R. L. .
JOURNAL OF CLINICAL PATHOLOGY, 2009, 62 (06) :516-518
[4]   The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei [J].
Carr, Norman J. ;
Bibeau, Frederic ;
Bradley, Robert F. ;
Dartigues, Peggy ;
Feakins, Roger M. ;
Geisinger, Kim R. ;
Gui, Xianyong ;
Isaac, Sylvie ;
Milione, Massimo ;
Misdraji, Joseph ;
Pai, Reetesh K. ;
Rodriguez-Justo, Manuel ;
Sobin, Leslie H. ;
van Velthuysen, Marie-Louise F. ;
Yantiss, Rhonda K. .
HISTOPATHOLOGY, 2017, 71 (06) :847-858
[5]  
Carr NJ, 2016, AM J SURG PATHOL, V40, P14, DOI 10.1097/PAS.0000000000000535
[6]   Genetic analysis of synchronous mucinous tumors of the ovary and appendix [J].
Chuaqui, RF ;
Zhuang, ZP ;
Emmertbuck, MR ;
Bryant, BR ;
Nogales, F ;
Tavassoli, FA ;
Merino, MJ .
HUMAN PATHOLOGY, 1996, 27 (02) :165-171
[7]   Synchronous mucinous tumors of the appendix and the ovary associated with pseudomyxoma peritonei - A clinicopathologic study of six cases with comparative analysis of c-Ki-ras mutations [J].
Cuatrecasas, M ;
MatiasGuiu, X ;
Prat, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (06) :739-746
[8]   EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix [J].
Dimmler, Arno ;
Geddert, Helene ;
Faller, Gerhard .
PATHOLOGY RESEARCH AND PRACTICE, 2014, 210 (05) :274-278
[9]   Guilty as charged: B-RAF is a human oncogene [J].
Garnett, MJ ;
Marais, R .
CANCER CELL, 2004, 6 (04) :313-319
[10]   A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix [J].
Hara, Kieko ;
Saito, Tsuyoshi ;
Hayashi, Takuo ;
Yimit, Alkam ;
Takahashi, Michiko ;
Mitani, Keiko ;
Takahashi, Makoto ;
Yao, Takashi .
PATHOLOGY RESEARCH AND PRACTICE, 2015, 211 (09) :657-664