Facile biomimetic syntheses of the azaspiracid spiroaminal

被引：16

作者：

Nguyen, Son ^{[1
]}

Xu, Jianyan ^{[1
]}

Forsyth, Craig J. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 22期

关键词：

D O I：

10.1016/j.tet.2006.01.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The azaspiracid natural products display a common spiroaminal-containing terminal domain that has inspired the development of two new methods for spiroaminal syntheses-a Staudinger reduction-aza-Wittig process and a double intramolecular hetero-Michael addition. These effective laboratory approaches proceed through imine and enamine intermediates that may reflect transient biogenetic species. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：5338 / 5346

页数：9

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