High-throughput approaches to understanding gene function and mapping network architecture in bacteria

被引：41

作者：

Brochado, Ana Rita ^{[1
]}

Typas, Athanasios ^{[1
]}

机构：

[1] European Mol Biol Lab, Genome Biol Unit, D-69117 Heidelberg, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2013年 / 16卷 / 02期

关键词：

TRANSPOSON MUTANT LIBRARY; RNAI SCREEN; GENOME; YEAST; IDENTIFICATION; ANTIBIOTICS; INHIBITOR; VIRULENCE; EVOLUTION; SELECTION;

D O I：

10.1016/j.mib.2013.01.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Advances in sequencing technology have provided an unprecedented view of bacterial diversity, along with a daunting number of novel genes. Within this new reality lies the challenge of developing large-scale approaches to assign function to the new genes and place them in pathways. Here, we highlight recent advances on this front, focusing on how high-throughput gene-gene, gene-drug and drug-drug interactions can yield functional and mechanistic inferences in bacteria.

引用

页码：199 / 206

页数：8

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