Epigenetic biomarkers in urological tumors: A systematic review

被引：72

作者：

Jeronimo, Carmen ^{[1
,2
,4
]}

Henrique, Rui ^{[1
,3
,4
]}

机构：

[1] Portuguese Oncol Inst, Res Ctr, Canc Epigenet Grp, P-4200072 Oporto, Portugal

[2] Portuguese Oncol Inst, Dept Genet, P-4200072 Oporto, Portugal

[3] Portuguese Oncol Inst, Dept Pathol, P-4200072 Oporto, Portugal

[4] Univ Porto, Inst Biomed Sci Abel Salazar, Dept Pathol & Mol Immunol, P-4099003 Oporto, Portugal

来源：

CANCER LETTERS | 2014年 / 342卷 / 02期

关键词：

Epigenetic-based biomarkers; Genitourinary cancer; DNA methylation; Histone modifications; microRNAs; CPG ISLAND HYPERMETHYLATION; PROSTATE-CANCER DETECTION; GLOBAL DNA-METHYLATION; RENAL-CELL CARCINOMA; ABERRANT PROMOTER METHYLATION; HISTONE MODIFICATION PATTERNS; POLYMERASE-CHAIN-REACTION; ANTAGONIST FAMILY GENES; GROUP PROTEIN EZH2; BLADDER-CANCER;

D O I：

10.1016/j.canlet.2011.12.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate, bladder, kidney and testis cancers, the most common genitourinary (GU) neoplasms, are generally clinically silent at their earliest stages when curative treatment is most likely successful. However, there are no consensual guidelines for GU cancer screening and available methods are characterized by suboptimal sensitivity and specificity. Moreover, standard clinical and pathological parameters meet with important limitations in the assessment of prognosis in an individual basis. Herein, we focus on the development of epigenetic-based GU cancer biomarkers, which have emerged from exploratory studies in recent years and that hold the promise to revolutionize the clinical management of GU cancer patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：264 / 274

页数：11

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