Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates

被引：57

作者：

Erakovic, S. ^{[1
]}

Jankovic, A. ^{[1
]}

Ristoscu, C. ^{[2
]}

Duta, L. ^{[2
]}

Serban, N. ^{[2
]}

Visan, A. ^{[2
]}

Mihailescu, I. N. ^{[2
]}

Stan, G. E. ^{[3
]}

Socol, M. ^{[3
]}

Iordache, O. ^{[4
]}

Dumitrescu, I. ^{[4
]}

Luculescu, C. R. ^{[2
]}

Janackovic, Dj. ^{[1
]}

Miskovic-Stankovic, V. ^{[1
]}

机构：

[1] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia

[2] Natl Inst Lasers Plasma & Radiat Phys, Magurele Ilfov 077125, Romania

[3] Natl Inst Mat Phys, Magurele Ilfov 077125, Romania

[4] Natl Inst Text & Leather, Bucharest 030508, Romania

来源：

APPLIED SURFACE SCIENCE | 2014年 / 293卷

关键词：

Antifungal activity; Ag doped thin films; TiO2; nanotubes; Hydroxyapatite; Pulsed laser deposition; CALCIUM-PHOSPHATE COATINGS; SIMULATED BODY-FLUID; ANTIMICROBIAL ACTIVITY; IMPLANT APPLICATIONS; HYDROXYAPATITE; TITANIUM; SILVER; ANTIBACTERIAL; BONE; BIOACTIVITY;

D O I：

10.1016/j.apsusc.2013.12.029

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag:HA thin films showed the highest antifungal activity. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：37 / 45

页数：9

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