ROS homeostasis and metabolism: a critical liaison for cancer therapy

被引：246

作者：

Kim, Jongdoo ^{[1
]}

Kim, Jaehong ^{[2
,3
]}

Bae, Jong-Sup ^{[4
]}

机构：

[1] Gachon Univ, Gil Med Ctr, Canc Control Team, Inchon, South Korea

[2] Gachon Univ, Sch Med, Dept Biochem, 155 Gaetbeol Ro, Inchon 21999, South Korea

[3] Gachon Univ, Gachon Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Inchon, South Korea

[4] Pharmaceut Sci Res Inst, CMRI, Coll Pharm, Daegu, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2016年 / 48卷

基金：

新加坡国家研究基金会;

关键词：

PYRUVATE-DEHYDROGENASE KINASE; INDUCIBLE FACTOR-I; MITOCHONDRIAL OXIDATIVE-METABOLISM; PROTEIN-TYROSINE KINASES; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; LACTATE-DEHYDROGENASE; REDOX REGULATION; BREAST-CANCER; 6-PHOSPHOFRUCTO-2-KINASE PFKFB3;

D O I：

10.1038/emm.2016.119

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus, important steps toward developing novel cancer therapy approaches would be to identify and modulate critical biochemical nodes that are deregulated in cancer metabolism and determine if the therapeutic efficiency can be influenced by changes in redox homeostasis in cancer tissues. In this review, we will explore the molecular mechanisms responsible for the metabolic reprogramming of tumor microenvironments, the functional modulation of which may disrupt the effects of or may be disrupted by redox homeostasis modulating cancer therapy.

引用

页码：e269 / e269

页数：13

共 186 条

[1] Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia [J].

Agbor, Terence A. ;

Cheong, Alex ;

Comerford, Katrina M. ;

Scholz, Carsten C. ;

Bruning, Ulrike ;

Clarke, Ambrose ;

Cummins, Eoin P. ;

Cagney, Gerard ;

Taylor, Cormac T. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (06) :4718-4726

[2] Normal and cancer cell metabolism: lymphocytes and lymphoma [J].

Altman, Brian J. ;

Dang, Chi V. .

FEBS JOURNAL, 2012, 279 (15) :2598-2609

[3] Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [J].

Anastasiou, Dimitrios ;

Yu, Yimin ;

Israelsen, William J. ;

Jiang, Jian-Kang ;

Boxer, Matthew B. ;

Hong, Bum Soo ;

Tempel, Wolfram ;

Dimov, Svetoslav ;

Shen, Min ;

Jha, Abhishek ;

Yang, Hua ;

Mattaini, Katherine R. ;

Metallo, Christian M. ;

Fiske, Brian P. ;

Courtney, Kevin D. ;

Malstrom, Scott ;

Khan, Tahsin M. ;

Kung, Charles ;

Skoumbourdis, Amanda P. ;

Veith, Henrike ;

Southall, Noel ;

Walsh, Martin J. ;

Brimacombe, Kyle R. ;

Leister, William ;

Lunt, Sophia Y. ;

Johnson, Zachary R. ;

Yen, Katharine E. ;

Kunii, Kaiko ;

Davidson, Shawn M. ;

Christofk, Heather R. ;

Austin, Christopher P. ;

Inglese, James ;

Harris, Marian H. ;

Asara, John M. ;

Stephanopoulos, Gregory ;

Salituro, Francesco G. ;

Jin, Shengfang ;

Dang, Lenny ;

Auld, Douglas S. ;

Park, Hee-Won ;

Cantley, Lewis C. ;

Thomas, Craig J. ;

Heiden, Matthew G. Vander .

NATURE CHEMICAL BIOLOGY, 2012, 8 (10) :839-847

[4] Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses [J].

Anastasiou, Dimitrios ;

Poulogiannis, George ;

Asara, John M. ;

Boxer, Matthew B. ;

Jiang, Jian-kang ;

Shen, Min ;

Bellinger, Gary ;

Sasaki, Atsuo T. ;

Locasale, Jason W. ;

Auld, Douglas S. ;

Thomas, Craig J. ;

Vander Heiden, Matthew G. ;

Cantley, Lewis C. .

SCIENCE, 2011, 334 (6060) :1278-1283

[5] Mitochondrial metabolism of reactive oxygen species [J].

Andreyev, AI ;

Kushnareva, YE ;

Starkov, AA .

BIOCHEMISTRY-MOSCOW, 2005, 70 (02) :200-214

[6] The role of glutathione in brain tumor drug resistance [J].

Backos, Donald S. ;

Franklin, Christopher C. ;

Reigan, Philip .

BIOCHEMICAL PHARMACOLOGY, 2012, 83 (08) :1005-1012

[7] Cysteine-mediated redox signalling in the mitochondria [J].

Bak, D. W. ;

Weerapana, E. .

MOLECULAR BIOSYSTEMS, 2015, 11 (03) :678-697

[8] ATP citrate lyase is an important component of cell growth and transformation [J].

Bauer, DE ;

Hatzivassiliou, G ;

Zhao, FP ;

Andreadis, C ;

Thompson, CB .

ONCOGENE, 2005, 24 (41) :6314-6322

[9] PTP1B: mediating ROS signaling to silence genes [J].

Boivin, Benoit ;

Tonks, Nicholas K. .

MOLECULAR & CELLULAR ONCOLOGY, 2015, 2 (02)

[10] Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site [J].

Bonello, Steve ;

Zahringer, Christian ;

BelAiba, Rachida S. ;

Djordjevic, Talija ;

Hess, John ;

Michiels, Carine ;

Kietzmann, Thomas ;

Goerlach, Agnes .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (04) :755-761

← 1 2 3 4 5 6 7 8 9 10 →