Influence of R-CHOP Therapy on Immune System Restoration in Patients with B-Cell Lymphoma

被引：21

作者：

Ito, Kaori ^{[1
,2
]}

Okamoto, Masataka ^{[2
]}

Inaguma, Yoko ^{[2
]}

Okamoto, Akinao ^{[2
]}

Ando, Maiko ^{[1
,2
]}

Ando, Yosuke ^{[1
]}

Tsuge, Masahiro ^{[1
]}

Tomono, Ayana ^{[1
]}

Kakumae, Yukiko ^{[1
]}

Hayashi, Takahiro ^{[1
]}

Yamada, Shigeki ^{[1
]}

Emi, Nobuhiko ^{[2
]}

机构：

[1] Fujita Hlth Univ Hosp, Dept Pharm, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan

[2] Fujita Hlth Univ, Sch Med, Dept Hematol, Toyoake, Aichi, Japan

来源：

ONCOLOGY | 2016年 / 91卷 / 06期

关键词：

B-cell lymphoma; R-CHOP therapy; Immune system; Serum IgG; CD4+lymphocyte; CHEMOTHERAPY PLUS RITUXIMAB; NON-HODGKINS-LYMPHOMA; FOLLICULAR LYMPHOMA; IMMUNOGLOBULIN LEVELS; PROLONGED TREATMENT; LOW-GRADE; RECONSTITUTION; HYPOGAMMAGLOBULINEMIA; REMISSION; SURVIVAL;

D O I：

10.1159/000449251

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To assess the immunosuppressive effect of R CHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (slgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median slgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. slgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. Conclusion: The immuno-suppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for >2 years, although slgG levels were restored more quickly than CD4+ cell counts. (C) 2016 S. Karger AG, Basel

引用

页码：302 / 310

页数：9

共 26 条

[1] B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny [J].