共 20 条
Differential Contributions of STAT5A and STAT5B to Stress Protection and Tyrosine Kinase Inhibitor Resistance of Chronic Myeloid Leukemia Stem/Progenitor Cells
被引:59
作者:

Casetti, Luana
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France
Univ Paris 05, Paris, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Martin-Lanneree, Severine
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France
Univ Paris 05, Paris, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Najjar, Imen
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France
Univ Paris 05, Paris, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Plo, Isabelle
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U1009, Villejuif, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Auge, Sylvie
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France
Univ Paris 05, Paris, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Roy, Lydia
论文数: 0 引用数: 0
h-index: 0
机构:
CHU, INSERM, CIC0802, Poitiers, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Chomel, Jean-Claude
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, INSERM, U935, Poitiers, France
CHU, Poitiers, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Lauret, Evelyne
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France
Univ Paris 05, Paris, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

Turhan, Ali G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, INSERM, U935, Poitiers, France
CHU, Poitiers, France Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France

论文数: 引用数:
h-index:
机构:
机构:
[1] Inst Cochin Genet Mol, Inserm U1016, F-75014 Paris, France
[2] Univ Paris 05, Paris, France
[3] INSERM, U1009, Villejuif, France
[4] CHU, INSERM, CIC0802, Poitiers, France
[5] Univ Poitiers, INSERM, U935, Poitiers, France
[6] CHU, Poitiers, France
关键词:
CHRONIC MYELOGENOUS LEUKEMIA;
OXIDATIVE STRESS;
IMATINIB;
ACTIVATION;
EXPRESSION;
GENE;
D O I:
10.1158/0008-5472.CAN-12-3955
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
STAT5 fulfills essential roles in hematopoietic stem cell (HSC) self-renewal and chronic myeloid leukemia (CML), a prototypical stem cell malignancy. However, the specific contributions of the two related genes STAT5A and STAT5B have not been determined. In this study, we used a RNAi-based strategy to establish participation of these genes to CML disease and persistence following targeted therapy. We showed that STAT5A/STAT5B double-knockdown triggers CML cell apoptosis and suppresses both normal and CML HSC long-term clonogenic potential. STAT5A and STAT5B exhibited similar prosurvival activity, but STAT5A attenuation alone was ineffective at impairing growth of normal and CML CD34(+) cells isolated at diagnosis. In contrast, STAT5A attenuation was sufficient to enhance basal oxidative stress and DNA damage of normal CD34(+) and CML cells. Furthermore, it weakened the ability to manage exogenous oxidative stress, increased p53 (TRP53)/CHK-2 (CHEK2) stress pathway activation, and enhanced prolyl hydroxylase domain (PHD)-3 (EGLN3) mRNA expression. Only STAT5A and its transactivation domain-deficient mutant STAT5A Delta 749 specifically rescued these activities. STAT5A attenuation was also active at inhibiting growth of CML CD34(+) cells from patients with acquired resistance to imatinib. Our findings show that STAT5A has a selective role in contributing to stress resistance through unconventional mechanisms, offering new opportunities to eradicate the most primitive and tyrosine kinase inhibitor-resistant CML cells with an additional potential to eradicate persistent stem cell populations. Cancer Res; 73(7); 2052-8. (C)2013 AACR.
引用
收藏
页码:2052 / 2058
页数:7
相关论文
共 20 条
[1]
Maximal lentivirus-mediated gene transfer and sustained transgene expression in human hematopoietic primitive cells and their progeny
[J].
Amsellem, S
;
Ravet, E
;
Fichelson, S
;
Pflumio, F
;
Dubart-Kupperschmitt, A
.
MOLECULAR THERAPY,
2002, 6 (05)
:673-677

Amsellem, S
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France

Ravet, E
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France

Fichelson, S
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France

Pflumio, F
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France

Dubart-Kupperschmitt, A
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France CNRS, INSERM, Inst Cochin, UMR 8104,U567,Hematol Dept,Matern Port Royal, F-75014 Paris, France
[2]
Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cells
[J].
Cholez, E.
;
Debuysscher, V.
;
Bourgeais, J.
;
Boudot, C.
;
Leprince, J.
;
Tron, F.
;
Brassart, B.
;
Regnier, A.
;
Bissac, E.
;
Pecnard, E.
;
Gouilleux, F.
;
Lassoued, K.
;
Gouilleux-Gruart, V.
.
LEUKEMIA,
2012, 26 (11)
:2390-2397

Cholez, E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Debuysscher, V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Bourgeais, J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Boudot, C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Leprince, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, INSERM, Plate Forme Rech Imagerie Cellulaire Haute Norman, IRIB,U982, Mont St Aignan, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Tron, F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, INSERM, CHU, U905, Rouen, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Brassart, B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, FRE 3481, MEDyC, Reims, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

论文数: 引用数:
h-index:
机构:

Bissac, E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Pecnard, E.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Gouilleux, F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Lassoued, K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France

Gouilleux-Gruart, V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France Univ Picardie Jules Verne, Dept Immunol, INSERM, CHU Amiens,U925, Amiens, France
[3]
Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease
[J].
Chomel, Jean-Claude
;
Bonnet, Marie-Laure
;
Sorel, Nathalie
;
Bertrand, Angelina
;
Meunier, Marie-Claude
;
Fichelson, Serge
;
Melkus, Michael
;
Bennaceur-Griscelli, Annelise
;
Guilhot, Francois
;
Turhan, Ali G.
.
BLOOD,
2011, 118 (13)
:3657-3660

Chomel, Jean-Claude
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inserm U935, Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Bonnet, Marie-Laure
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inserm U935, Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Sorel, Nathalie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inserm U935, Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Bertrand, Angelina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inserm U935, Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Meunier, Marie-Claude
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inserm U935, Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Fichelson, Serge
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Inserm U1016, Inst Cochin, Paris, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Melkus, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 11, Inserm U935, Paris, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Bennaceur-Griscelli, Annelise
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 11, Inserm U935, Paris, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Guilhot, Francois
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inserm U935, Poitiers, France
CHU Poitiers, Inserm CIC 0802, F-86021 Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France

Turhan, Ali G.
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France
Univ Poitiers, Inserm U935, Poitiers, France CHU Poitiers, Inserm U935, Serv Hematol & Oncol Biol, F-86021 Poitiers, France
[4]
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
[J].
Corbin, Amie S.
;
Agarwal, Anupriya
;
Loriaux, Marc
;
Cortes, Jorge
;
Deininger, Michael W.
;
Druker, Brian J.
.
JOURNAL OF CLINICAL INVESTIGATION,
2011, 121 (01)
:396-409

Corbin, Amie S.
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA
Howard Hughes Med Inst, Portland, OR USA Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA

Agarwal, Anupriya
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA

Loriaux, Marc
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA
Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97293 USA Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA

Cortes, Jorge
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA

Deininger, Michael W.
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA

Druker, Brian J.
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA
Howard Hughes Med Inst, Portland, OR USA Oregon Hlth & Sci Univ, Inst Canc, Div Hematol & Med Oncol, Portland, OR 97293 USA
[5]
INDUCTION OF CHRONIC MYELOGENOUS LEUKEMIA IN MICE BY THE P210BCR/ABL GENE OF THE PHILADELPHIA-CHROMOSOME
[J].
DALEY, GQ
;
VANETTEN, RA
;
BALTIMORE, D
.
SCIENCE,
1990, 247 (4944)
:824-830

DALEY, GQ
论文数: 0 引用数: 0
h-index: 0
机构: BRIGHAM & WOMENS HOSP, DIV HEMATOL, BOSTON, MA 02115 USA

VANETTEN, RA
论文数: 0 引用数: 0
h-index: 0
机构: BRIGHAM & WOMENS HOSP, DIV HEMATOL, BOSTON, MA 02115 USA

BALTIMORE, D
论文数: 0 引用数: 0
h-index: 0
机构: BRIGHAM & WOMENS HOSP, DIV HEMATOL, BOSTON, MA 02115 USA
[6]
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
[J].
Druker, Brian J.
;
Guilhot, Francois
;
O'Brien, Stephen G.
;
Gathmann, Insa
;
Kantarjian, Hagop
;
Gattermann, Norbert
;
Deininger, Michael W. N.
;
Silver, Richard T.
;
Goldman, John M.
;
Stone, Richard M.
;
Cervantes, Francisco
;
Hochhaus, Andreas
;
Powell, Bayard L.
;
Gabrilove, Janice L.
;
Rousselot, Philippe
;
Reiffers, Josy
;
Cornelissen, Jan J.
;
Hughes, Timothy
;
Agis, Hermine
;
Fischer, Thomas
;
Verhoef, Gregor
;
Shepherd, John
;
Saglio, Giuseppe
;
Gratwohl, Alois
;
Nielsen, Johan L.
;
Radich, Jerald P.
;
Simonsson, Bengt
;
Taylor, Kerry
;
Baccarani, Michele
;
So, Charlene
;
Letvak, Laurie
;
Larson, Richard A.
.
NEW ENGLAND JOURNAL OF MEDICINE,
2006, 355 (23)
:2408-2417

Druker, Brian J.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Guilhot, Francois
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

O'Brien, Stephen G.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Gathmann, Insa
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Kantarjian, Hagop
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Gattermann, Norbert
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Deininger, Michael W. N.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Silver, Richard T.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Goldman, John M.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Stone, Richard M.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Cervantes, Francisco
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Hochhaus, Andreas
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Powell, Bayard L.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Gabrilove, Janice L.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Rousselot, Philippe
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Reiffers, Josy
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Cornelissen, Jan J.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Hughes, Timothy
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Agis, Hermine
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Fischer, Thomas
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Verhoef, Gregor
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Shepherd, John
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Saglio, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Gratwohl, Alois
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Nielsen, Johan L.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Radich, Jerald P.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Simonsson, Bengt
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Taylor, Kerry
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Baccarani, Michele
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

So, Charlene
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Letvak, Laurie
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

Larson, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA
[7]
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
[J].
Harir, Noria
;
Pecquet, Christian
;
Kerenyi, Marc
;
Sonneck, Karoline
;
Kovacic, Boris
;
Nyga, Remy
;
Brevet, Marie
;
Dhennin, Isabelle
;
Gouilleux-Gruart, Valerie
;
Beug, Hartmut
;
Valent, Peter
;
Lassoued, Kaiss
;
Moriggl, Richard
;
Gouilleux, Fabrice
.
BLOOD,
2007, 109 (04)
:1678-1686

Harir, Noria
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Pecquet, Christian
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Kerenyi, Marc
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Sonneck, Karoline
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Kovacic, Boris
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Nyga, Remy
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Brevet, Marie
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Dhennin, Isabelle
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Gouilleux-Gruart, Valerie
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Beug, Hartmut
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Valent, Peter
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

Lassoued, Kaiss
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France

论文数: 引用数:
h-index:
机构:

Gouilleux, Fabrice
论文数: 0 引用数: 0
h-index: 0
机构: Univ Picardie, Fac Med, INSERM, EMI 351, F-80036 Amiens, France
[8]
Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
[J].
Hennighausen, Lothar
;
Robinson, Gertraud W.
.
GENES & DEVELOPMENT,
2008, 22 (06)
:711-721

Hennighausen, Lothar
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA

Robinson, Gertraud W.
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA
[9]
P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
[J].
Ilaria, RL
;
VanEtten, RA
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1996, 271 (49)
:31704-31710

Ilaria, RL
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,DEPT GENET,CTR BLOOD RES,BOSTON,MA 02115

VanEtten, RA
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,DEPT GENET,CTR BLOOD RES,BOSTON,MA 02115
[10]
Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A
[J].
Kazansky, AV
;
Kabotyanski, EB
;
Wyszomierski, SL
;
Mancini, MA
;
Rosen, JM
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (32)
:22484-22492

Kazansky, AV
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

Kabotyanski, EB
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

Wyszomierski, SL
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

Mancini, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

Rosen, JM
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA