Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature

被引:52
作者
Chavez, Cinderella [1 ]
Hoffman, Mark A. [1 ]
机构
[1] North Shore LIJ Hlth Syst, Dept Med, Div Hematol Oncol, Long Isl Jewish Med Ctr, New Hyde Pk, NY 11040 USA
关键词
inflammatory myofibroblastic tumor; non-steroidal anti-inflammatory agents; cyclooxygenase-2; inhibitors; PSEUDOTUMOR; LIVER; REGRESSION; THERAPY;
D O I
10.3892/ol.2013.1260
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report a case in which a 52-year-old female developed a multifocal inflammatory myofibroblastic tumor (IMT) of the lung. The tumor did not overexpress the anaplastic lymphoma kinase (ALK) protein, indicating a lack of ALK rearrangement. The patient required two wedge resections in 15 months due to recurrent disease. Recurrence after the second surgery was treated with corticosteroids, which only led to a transient response (6 months). Introduction of celecoxib, a cyclooxygenase-2 inhibitor, induced a complete remission in the patient. Maintenance on celecoxib further led to a progression-free survival of 34 months. A literature review retrieved a total of eight case reports, comprising ten patients, of IMT of various anatomical sites successfully treated with non-steroidal anti-inflammatory agent (NSAID) therapy. Nine of the ten patients achieved durable complete remission. Remission occurred rapidly and persisted even after termination of NSAID therapy. Although such a successful outcome may only be achieved rarely, a trial of an NSAID should be considered in any patient in whom complete resection is not an option. Our case also demonstrates that NSAID therapy may be successful in a non-ALK rearranged tumor in which ALK inhibition is not an option.
引用
收藏
页码:1672 / 1676
页数:5
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