Triboelectrification of active pharmaceutical ingredients: week acids and their salts

被引：3

作者：

Fujinuma, Kenta ^{[1
,2
]}

Ishii, Yuji ^{[1
]}

Yashihashi, Yasuo ^{[1
]}

Yonemochi, Estuo ^{[3
]}

Sugano, Kiyohiko ^{[1
]}

Tarada, Katsuhide ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

[2] Nippon Chemiphar Co Ltd, Gener Pharmaceut Dev Dept, Misato, Saitama 3410005, Japan

[3] Hoshi Univ, Sch Pharm & Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2015年 / 493卷 / 1-2期

关键词：

Triboelectrification; Active pharmaceutical ingredient; Weak acid; Sodium salt; Zero-charge margin; Standard carrier beads; ELECTRIFICATION; MICRONIZATION; POWDERS; SURFACE;

D O I：

10.1016/j.ijpharm.2015.08.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of salt formulation on the electrostatic property of active pharmaceutical ingredients was investigated. The electrostatic property of weak acids (carboxylic acids and amide-enole type acid) and their sodium salts was evaluated by a suction-type Faraday cage meter. Free carboxylic acids showed negative chargeability, whereas their sodium salts showed more positive chargeability than the free acids. However, no such trend was observed for amide-enole type acids. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：434 / 438

页数：5

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