Successful induction and consolidation therapy of acute myeloid leukaemia in a renal allograft recipient

被引：11

作者：

Gorschluter, M ^{[1
]}

Glasmacher, A ^{[1
]}

Risse, F ^{[1
]}

Klein, B ^{[1
]}

Klehr, HU ^{[1
]}

Mezger, J ^{[1
]}

机构：

[1] UNIV BONN, DEPT GEN INT MED, D-5300 BONN, GERMANY

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 1997年 / 12卷 / 03期

关键词：

acute myeloid leukaemia; chemotherapy; immunosuppression; infections; renal transplantation;

D O I：

10.1093/ndt/12.3.593

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Immunosuppressed organ transplant recipients have a markedly increased risk of neoplasia. Among these malignancies acute myeloid leukaemia (AML) is rare. However, until now no case of successful chemotherapy has been reported. We present a 39-year-old male patient who developed AML (FAB M4 Eo) 4 years after renal transplantation and achieved a stable complete remission after induction therapy with standard dose cytarabine and daunorubicin. Remission duration is now 11 months. At present the transplant is functioning well after two additional courses of consolidation chemotherapy with high-dose cytarabine combined with mitoxantrone and idarubicine respectively. Cyclosporin A was given during all cycles of chemotherapy. We conclude that intensive chemotherapy in patients with AML following renal transplantation in good performance status is feasible.

引用

页码：593 / 595

页数：3

共 11 条

[1]

BLOOMFIELD CD, 1994, BLOOD, V84, pA111

[2]

BUTLER J, 1990, TRANSPLANTATION, V49, P813

[3] TREATMENT OF ACUTE MYELOID-LEUKEMIA IN A RENAL-ALLOGRAFT RECIPIENT - IMPLICATIONS OF CYCLOSPORINE IMMUNOSUPPRESSIVE TREATMENT [J].