A microfluidic microbial culture device for rapid determination of the minimum inhibitory concentration of antibiotics

被引：28

作者：

Takagi, Rika ^{[1
]}

Fukuda, Junji ^{[1
]}

Nagata, Keiji ^{[2
]}

Yawata, Yutaka ^{[2
]}

Nomura, Nobuhiko ^{[2
]}

Suzuki, Hiroaki ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058572, Japan

[2] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan

来源：

ANALYST | 2013年 / 138卷 / 04期

关键词：

SUSCEPTIBILITY;

D O I：

10.1039/c2an36323b

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A microfluidic device was developed for rapid determination of the minimum inhibitory concentration (MIC) of antibiotics against bacteria. A small volume of sample solution was introduced into multiple chambers simultaneously, and the growth of bacteria was quantified using a noninvasive three-dimensional (3D) visualization technique.

引用

页码：1000 / 1003

页数：4

共 14 条

[1] Millifluidic droplet analyser for microbiology [J].

Baraban, Larysa ;

Bertholle, Fabien ;

Salverda, Merijn L. M. ;

Bremond, Nicolas ;

Panizza, Pascal ;

Baudry, Jean ;

de Visser, J. Arjan G. M. ;

Bibette, Jerome .

LAB ON A CHIP, 2011, 11 (23) :4057-4062

[2] Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics [J].

Boedicker, James Q. ;

Li, Liang ;

Kline, Timothy R. ;

Ismagilov, Rustem F. .

LAB ON A CHIP, 2008, 8 (08) :1265-1272

[3] Toward resolving the challenges of sepsis diagnosis [J].

Carrigan, SD ;

Scott, G ;

Tabrizian, M .

CLINICAL CHEMISTRY, 2004, 50 (08) :1301-1314

[4] A self-loading microfluidic device for determining the minimum inhibitory concentration of antibiotics [J].

Cira, Nate J. ;

Ho, Jack Y. ;

Dueck, Megan E. ;

Weibel, Douglas B. .

LAB ON A CHIP, 2012, 12 (06) :1052-1059

[5] Experimental reproducibility in flow-chamber biofilms [J].

Heydorn, A ;

Ersboll, BK ;

Hentzer, M ;

Parsek, MR ;

Givskov, M ;

Molin, S .

MICROBIOLOGY-UK, 2000, 146 :2409-2415

[6] In situ monitoring of antibiotic susceptibility of bacterial biofilms in a microfluidic device [J].

Kim, Keun Pil ;

Kim, Yun-Gon ;

Choi, Chang-Hyung ;

Kim, Hye-Eun ;

Lee, Sang-Ho ;

Chang, Woo-Suk ;

Lee, Chang-Soo .

LAB ON A CHIP, 2010, 10 (23) :3296-3299

[7] Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia [J].

Kurahashi, Kiyoyasu ;

Sawa, Teiji ;

Ota, Maria ;

Kajikawa, Osamu ;

Hong, Keelung ;

Martin, Thomas R. ;

Wiener-Kronish, Jeanine P. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 296 (02) :L198-L209

[8] Electrochemical microsystem with porous matrix packed-beds for enzyme analysis [J].

Morimoto, Katsuya ;

Upadhyay, Sanjay ;

Higashiyama, Terutaka ;

Ohgami, Naoto ;

Kusakabe, Hitoshi ;

Fukuda, Junji ;

Suzuki, Hiroaki .

SENSORS AND ACTUATORS B-CHEMICAL, 2007, 124 (02) :477-485

[9] Advances in microfluidic PCR for point-of-care infectious disease diagnostics [J].

Park, Seungkyung ;

Zhang, Yi ;

Lin, Shin ;

Wang, Tza-Huei ;

Yang, Samuel .

BIOTECHNOLOGY ADVANCES, 2011, 29 (06) :830-839

[10] Coulometric Detection of Components in Liquid Plugs by Microfabricated Flow Channel and Electrode Structures [J].

Sassa, Fumihiro ;

Laghzali, Hind ;

Fukuda, Junji ;

Suzuki, Hiroaki .

ANALYTICAL CHEMISTRY, 2010, 82 (20) :8725-8732

← 1 2 →