Early-onset colorectal cancer in young individuals

被引：480

作者：

Mauri, Gianluca ^{[1
]}

Sartore-Bianchi, Andrea ^{[1
]}

Russo, Antonio-Giampiero ^{[2
]}

Marsoni, Silvia ^{[1
,3
]}

Bardelli, Alberto ^{[4
,5
]}

Siena, Salvatore ^{[1
]}

机构：

[1] Univ Milano La Statale, Dipartimento Oncol & Ematooncol, Grande Osped Metropolitano Niguarda, Niguarda Canc Ctr, Milan, Italy

[2] Agenzia Tutela Salute Citta Metropolitana Milano, Epidemiol Unit, Milan, Italy

[3] FIRC Inst Mol Oncol IFOM, Milan, Italy

[4] Univ Turin, Dept Oncol, Turin, Italy

[5] IRCCS, Candiolo Canc Inst FPO, Turin, Italy

来源：

MOLECULAR ONCOLOGY | 2019年 / 13卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

colorectal cancer; familial colorectal cancer; hereditary colorectal cancer; sporadic early-onset colorectal cancer; young adults; FAMILIAL ADENOMATOUS POLYPOSIS; CLINICAL-PRACTICE GUIDELINES; REVISED BETHESDA GUIDELINES; III COLON-CANCER; LYNCH-SYNDROME; GERMLINE MUTATIONS; MICROSATELLITE INSTABILITY; MOLECULAR-FEATURES; CLINICOPATHOLOGICAL CHARACTERISTICS; ADJUVANT CHEMOTHERAPY;

D O I：

10.1002/1878-0261.12417

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge in CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Early-onset CRC are characterized by a more advanced stage at diagnosis, poorer cell differentiation, higher prevalence of signet ring cell histology, and left colon-sided location of the primary tumor. Among EO-CRC, approximately 30% of patients are affected by tumors harboring mutations causing hereditary cancer predisposing syndromes, and 20% have familial CRC. Most notably, the remaining 50% of EO-CRC patients have neither hereditary syndromes nor familial CRC, thus representing a formidable challenge for research. In this review article we summarize epidemiology, clinical and molecular features, heredity and outcome of treatments of EO-CRC, and provide considerations for future perspectives.

引用

页码：109 / 131

页数：23

共 176 条

[1] Colorectal cancer outcomes and treatment patterns in patients too young for average-risk screening [J].

Abdelsattar, Zaid M. ;

Wong, Sandra L. ;

Regenbogen, Scott E. ;

Jomaa, Diana M. ;

Hardiman, Karin M. ;

Hendren, Samantha .

CANCER, 2016, 122 (06) :929-934

[2] Hereditary factors are unlikely behind unusual pattern of early - Onset colorectal cancer in Egyptians: A study of family history and pathology features in Egyptians with large bowel cancer (cross-sectional study) [J].

Abou-Zeid, Ahmed A. ;

Jumuah, Wael A. ;

Ebied, Essam F. ;

Atia, Karim Sabry Abd El Samee ;

El Ghamrini, Yasser ;

Somaie, Dina A. .

INTERNATIONAL JOURNAL OF SURGERY, 2017, 44 :71-75

[3] CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer [J].

Agesen, T. H. ;

Berg, M. ;

Clancy, T. ;

Thiis-Evensen, E. ;

Cekaite, L. ;

Lind, G. E. ;

Nesland, J. M. ;

Bakka, A. ;

Mala, T. ;

Hauss, H. J. ;

Fetveit, T. ;

Vatn, M. H. ;

Hovig, E. ;

Nesbakken, A. ;

Lothe, R. A. ;

Skotheim, R. I. .

GENES AND IMMUNITY, 2011, 12 (08) :653-662

[4] The Increasing Incidence of Young-Onset Colorectal Cancer: A Call to Action [J].

Ahnen, Dennis J. ;

Wade, Sally W. ;

Jones, Whitney F. ;

Sifri, Randa ;

Silveiras, Jose Mendoza ;

Greenamyer, Jasmine ;

Guiffre, Stephanie ;

Axilbund, Jennifer ;

Spiegel, Andrew ;

You, Y. Nancy .

MAYO CLINIC PROCEEDINGS, 2014, 89 (02) :216-224

[5] Effect of Oxaliplatin, Fluorouracil, and Leucovorin With or Without Cetuximab on Survival Among Patients With Resected Stage III Colon Cancer A Randomized Trial [J].

Alberts, Steven R. ;

Sargent, Daniel J. ;

Nair, Suresh ;

Mahoney, Michelle R. ;

Mooney, Margaret ;

Thibodeau, Stephen N. ;

Smyrk, Thomas C. ;

Sinicrope, Frank A. ;

Chan, Emily ;

Gill, Sharlene ;

Kahlenberg, Morton S. ;

Shields, Anthony F. ;

Quesenberry, James T. ;

Webb, Thomas A. ;

Farr, Gist H., Jr. ;

Pockaj, Barbara A. ;

Grothey, Axel ;

Goldberg, Richard M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (13) :1383-1393

[6] Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition [J].

Aleksandrova, Krasimira ;

Pischon, Tobias ;

Buijsse, Brian ;

May, Anne M. ;

Peeters, Petra H. ;

Bueno-de-Mesquita, H. Bas ;

Jenab, Mazda ;

Fedirko, Veronika ;

Dahm, Christina C. ;

Siersema, Peter D. ;

Freisling, Heinz ;

Ferrari, Pietro ;

Overvad, Kim ;

Tjonneland, Anne ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Naska, Androniki ;

Pala, Valeria ;

Mattiello, Amalia ;

Ohlsson, Bodil ;

Jirstrom, Karin ;

Key, Timothy J. ;

Khaw, Kay-Tee ;

Riboli, Elio ;

Boeing, Heiner .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (16) :3526-3536

[7] Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08 [J].

Allegra, Carmen J. ;

Yothers, Greg ;

O'Connell, Michael J. ;

Sharif, Saima ;

Petrelli, Nicholas J. ;

Colangelo, Linda H. ;

Atkins, James N. ;

Seay, Thomas E. ;

Fehrenbacher, Louis ;

Goldberg, Richard M. ;

O'Reilly, Seamus ;

Chu, Luis ;

Azar, Catherine A. ;

Lopa, Samia ;

Wolmark, Norman .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (01) :11-16

[8] Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years [J].

Alsop, Kathryn ;

Mead, Leeanne ;

Smith, Letitia D. ;

Royce, Simon G. ;

Tesoriero, Andrea A. ;

Young, Joanne P. ;

Haydon, Andrew ;

Grubb, Garry ;

Giles, Graham G. ;

Jenkins, Mark A. ;

Hopper, John L. ;

Southey, Melissa C. .

EUROPEAN JOURNAL OF CANCER, 2006, 42 (10) :1357-1361

[9]

[Anonymous], EUR J CANC OXF ENGL

[10]

[Anonymous], UNITED EUROPEAN GAST

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