Engineered nonviral nanocarriers for intracellular gene delivery applications

被引：32
作者：
Ojea-Jimenez, Isaac [1 ]
Tort, Olivia [2 ,3 ]
Lorenzo, Julia [2 ,3 ]
Puntes, Victor F. [1 ,4 ]
机构：
[1] ICN, Barcelona 08193, Spain
[2] Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Bellaterra 08193, Spain
[3] Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Bellaterra 08193, Spain
[4] ICREA, Barcelona 08010, Spain
来源：
BIOMEDICAL MATERIALS | 2012年 / 7卷 / 05期
关键词：
FUNCTIONALIZED CARBON NANOTUBES; MESOPOROUS SILICA NANOPARTICLES; SMALL INTERFERING RNA; MODIFIED GOLD NANOPARTICLES; CELLULAR UPTAKE; SIRNA DELIVERY; PLASMID DNA; QUANTUM-DOT; IN-VIVO; EFFICIENT DELIVERY;
D O I：
10.1088/1748-6041/7/5/054106
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The efficient delivery of nucleic acids into mammalian cells is a central aspect of cell biology and of medical applications, including cancer therapy and tissue engineering. Non-viral chemical methods have been received with great interest for transfecting cells. However, further development of nanocarriers that are biocompatible, efficient and suitable for clinical applications is still required. In this paper, the different material platforms for gene delivery are comparatively addressed, and the mechanisms of interaction with biological systems are discussed carefully.
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页数：13
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