Novel therapeutic approaches to post-infarction remodelling

被引：105

作者：

Fraccarollo, Daniela ^{[1
]}

Galuppo, Paolo ^{[1
]}

Bauersachs, Johann ^{[1
]}

机构：

[1] Hannover Med Sch, Klin Kardiol & Angiol, D-30175 Hannover, Germany

来源：

CARDIOVASCULAR RESEARCH | 2012年 / 94卷 / 02期

关键词：

Myocardial infarction; Ischaemia; Remodelling; MicroRNAs; Progenitor cells; Fibroblasts; Macrophages; ACUTE MYOCARDIAL-INFARCTION; BONE-MARROW-CELLS; CARDIAC STEM-CELLS; VENTRICULAR SYSTOLIC DYSFUNCTION; AUTOLOGOUS SKELETAL MYOBLASTS; HEART-FAILURE; ISCHEMIC CARDIOMYOPATHY; RECEPTOR BLOCKADE; GENE-THERAPY; PROGENITOR CELLS;

D O I：

10.1093/cvr/cvs109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adverse cardiac remodelling is a major cause of morbidity and mortality following acute myocardial infarction (MI). Mechanical and neurohumoral factors involved in structural and molecular post-infarction remodelling were important targets in research and treatment for years. More recently, therapeutic strategies that address myocardial regeneration and pathophysiological mechanisms of infarct wound healing appear to be useful novel tools to prevent progressive ventricular dilation, functional deterioration, life-threatening arrhythmia, and heart failure. This review provides an overview of future and emerging therapies for cardiac wound healing and remodelling after MI.

引用

页码：293 / 303

页数：11

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