MDSCs in infectious diseases: regulation, roles, and readjustment

被引：49

作者：

Dorhoi, Anca ^{[1
,2
,3
]}

Glaria, Estibaliz ^{[4
,5
]}

Garcia-Tellez, Thalia ^{[6
]}

Nieuwenhuizen, Natalie E. ^{[3
]}

Zelinskyy, Gennadiy ^{[7
]}

Favier, Benoit ^{[8
]}

Singh, Anurag ^{[9
,10
]}

Ehrchen, Jan ^{[11
]}

Gujer, Cornelia ^{[12
]}

Munz, Christian ^{[12
]}

Saraiva, Margarida ^{[13
,14
]}

Sohrabi, Yahya ^{[15
,16
]}

Sousa, Ana E. ^{[17
]}

Delputte, Peter ^{[18
]}

Mueller-Trutwin, Michaela ^{[6
]}

Valledor, Annabel F. ^{[4
,5
]}

机构：

[1] Friedrich Loeffler Inst, Inst Immunol, Fed Res Inst Anim Hlth, Sudufer 10, D-17493 Greifswald, Insel Riems, Germany

[2] Univ Greifswald, Fac Math & Nat Sci, Greifswald, Germany

[3] Max Planck Inst Infect Biol, Dept Immunol, Berlin, Germany

[4] Univ Barcelona, Nucl Receptor Grp, Dept Cell Biol Physiol & Immunol, Sch Biol, Ave Diagonal 643,3rd Floor, E-08028 Barcelona, Spain

[5] Univ Barcelona, Inst Biomed, Barcelona, Spain

[6] Inst Pasteur, HIV Inflammat & Persistence Unit, Paris, France

[7] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany

[8] Univ Paris Sud 11, Immunol Viral Infect & Autoimmune Dis IMVA, IDMIT Dept, CEA,INSERM,U1184,IBJF, Fontenay Aux Roses, France

[9] Univ Tubingen, Univ Childrens Hosp, Tubingen, Germany

[10] Univ Tubingen, Interdisciplinary Ctr Infect Dis, Tubingen, Germany

[11] Univ Hosp Munster, Dept Dermatol, Munster, Germany

[12] Univ Zurich, Viral Immunobiol, Inst Expt Immunol, Zurich, Switzerland

[13] i3S, Porto, Portugal

[14] Univ Porto, IBMC, Porto, Portugal

[15] Univ Hosp Munster, Mol & Translat Cardiol, Dept Cardiovasc Med, Munster, Germany

[16] Czech Acad Sci, Inst Mol Genet, Prague, Czech Republic

[17] Univ Lisbon, Fac Med, Inst Mol Med, Lisbon, Portugal

[18] Univ Antwerp, LMPH, Fac Pharmaceut Biomed & Vet Sci, Antwerp, Belgium

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2019年 / 68卷 / 04期

关键词：

Myeloid regulatory cells; MDSC; Infection; Immunosuppression; Oncogenic viruses; Mye-EUNITER; MYCOBACTERIUM-TUBERCULOSIS INFECTION; SUPPRESSOR-CELLS; T-CELLS; VIRUS-INFECTION; MYELOID CELLS; IMMUNE-RESPONSE; IFN-GAMMA; INHIBIT T; EXPANSION; INNATE;

D O I：

10.1007/s00262-018-2277-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.

引用

页码：673 / 685

页数：13

共 96 条

[1] Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis [J].