CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models

被引:49
作者
Chan, Chi-Ping
Kok, Kin-Hang
Jin, Dong-Yan [1 ]
机构
[1] Univ Hong Kong, LKS Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
关键词
ENDOPLASMIC-RETICULUM STRESS; REGULATED INTRAMEMBRANE PROTEOLYSIS; GRADE FIBROMYXOID SARCOMA; UNFOLDED PROTEIN RESPONSE; CREB/ATF-FAMILY; ER STRESS; PROSTATE-CANCER; LUMINAL DOMAIN; FATTY-ACIDS; LUMAN;
D O I
10.1186/2045-3701-1-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The CREB3 subfamily of membrane-bound bZIP transcription factors has five members in mammals known as CREB3 and CREB3L1-L4. One current model suggests that CREB3 subfamily transcription factors are similar to ATF6 in regulated intramembrane proteolysis and transcriptional activation. Particularly, they were all thought to be proteolytically activated in response to endoplasmic reticulum (ER) stress to stimulate genes that are involved in unfolded protein response (UPR). Although the physiological inducers of their proteolytic activation remain to be identified, recent findings from microarray analyses, RNAi screens and gene knockouts not only demonstrated their critical roles in regulating development, metabolism, secretion, survival and tumorigenesis, but also revealed cell type-specific patterns in the activation of their target genes. Members of the CREB3 subfamily show differential activity despite their structural similarity. The spectrum of their biological function expands beyond ER stress and UPR. Further analyses are required to elucidate the mechanism of their proteolytic activation and the molecular basis of their target recognition.
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页数:7
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