One-Pot Primary Aminomethylation of Aryl and Heteroaryl Halides with Sodium Phthalimidomethyltrifluoroborate

被引：23

作者：

Murai, Norio ^{[1
,2
]}

Miyano, Masayuki ^{[2
]}

Yonaga, Masahiro ^{[1
,2
]}

Tanaka, Keigo ^{[2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Eisai & Co Ltd, Discovery Res Labs, Tsukuba, Ibaraki 3002635, Japan

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 11期

关键词：

CHEMOSELECTIVE ACYLATION; REDUCTIVE AMINATION; AMINES; DOCKING;

D O I：

10.1021/ol301037s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki-Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.

引用

页码：2818 / 2821

页数：4

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