The role of protease activity in ErbB biology

被引：60

作者：

Blobel, Carl R. ^{[1
,2
]}

Carpenter, Graham ^{[3
]}

Freeman, Matthew ^{[4
]}

机构：

[1] Cornell Univ, Dept Med, Hosp Special Surg, Arthrit & Tissue Degenerat Program, New York, NY 10021 USA

[2] Cornell Univ, Weil Med Coll, Dept Physiol & Biophys, New York, NY 10021 USA

[3] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[4] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 04期

关键词：

ErbB receptor; Protease; Cleavage; Signal transduction; ALPHA-CONVERTING-ENZYME; GROWTH-FACTOR-ALPHA; INTRACELLULAR DOMAIN 4ICD; AMYLOID PRECURSOR PROTEIN; DROSOPHILA EGF RECEPTOR; DORSAL-VENTRAL AXIS; GAMMA-SECRETASE; INTRAMEMBRANE PROTEOLYSIS; TGF-ALPHA; TERMINAL FRAGMENT;

D O I：

10.1016/j.yexcr.2008.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proteases are now recognized as having an active role in a variety of processes aside from their recognized metabolic role in protein degradation. Within the ErbB system of ligands and receptors, proteases are known to be necessary for the generation of soluble ligands from transmembrane precursors and for the processing of the ErbB4 receptor, such that its intracellular domain is translocated to the nucleus. There are two protease activities involved in the events: proteases that cleave within the ectodomain of ligand (or receptor) and proteases that cleave the substrate within the transmembrane domain. The former are the ADAM proteases and the latter are the gamma-secretase complex and the rhomboid proteases. This review discusses the roles of each of these protease systems within the ErbB system. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：671 / 682

页数：12

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