Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

被引：31
|
作者：
Lau, King Hang Aaron [1 ]
Castelletto, Valeria [2 ]
Kendall, Thomas [3 ]
Sefcik, Jan [4 ]
Hamley, Ian W. [2 ]
Reza, Mehedi [5 ]
Ruokolainen, Janne [5 ]
机构：
[1] Univ Strathclyde, WestCHEM Dept Pure & Appl Chem, 99 George St, Glasgow G1 1RD, Lanark, Scotland
[2] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England
[3] Univ Strathclyde, EPSRC Doctoral Training Ctr Continuous Mfg & Crys, Dept Chem & Proc Engn, 75 Montrose St, Glasgow G1 1XJ, Lanark, Scotland
[4] Univ Strathclyde, Dept Chem & Proc Engn, 75 Montrose St, Glasgow G1 1XJ, Lanark, Scotland
[5] Aalto Univ, Sch Sci, Dept Appl Phys, POB 15100, FI-00076 Aalto, Finland
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 13期
基金：
英国工程与自然科学研究理事会;
关键词：
PEPTOID OLIGOMERS; PEPTIDE; BIOMATERIALS; POLYMERS;
D O I：
10.1039/c6cc09888f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Poly(N-substituted glycine) "peptoids'' constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.
引用
收藏
页码：2178 / 2181
页数：4
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