The complete genome sequence of the gastric pathogen Helicobacter pylori

被引:2906
作者
Tomb, JF
White, O
Kerlavage, AR
Clayton, RA
Sutton, GG
Fleischmann, RD
Ketchum, KA
Klenk, HP
Gill, S
Dougherty, BA
Nelson, K
Quackenbush, J
Zhou, LX
Kirkness, EF
Peterson, S
Loftus, B
Richardson, D
Dodson, R
Khalak, HG
Glodek, A
McKenney, K
Fitzegerald, LM
Lee, N
Adams, MD
Hickey, EK
Berg, DE
Gocayne, JD
Utterback, TR
Peterson, JD
Kelley, JM
Cotton, MD
Weldman, JM
Fujii, C
Bowman, C
Watthey, L
Wallin, E
Hayes, WS
Weidman, JM
Fujii, C
Borodovsky, M
Karp, PD
Smith, HO
Fraser, CM
Venter, JC
机构
[1] WASHINGTON UNIV,SCH MED,DEPT MOL BIOL,ST LOUIS,MO 63110
[2] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT BIOCHEM,S-10691 STOCKHOLM,SWEDEN
[3] GEORGIA TECH RES INST,SCH BIOL,ATLANTA,GA 30332
[4] SRI INT,CTR ARTIFICIAL INTELLIGENCE,MENLO PK,CA 94025
[5] JOHNS HOPKINS UNIV,SCH MED,DEPT MOL BIOL & GENET,BALTIMORE,MD 21205
关键词
D O I
10.1038/41483
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences, Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction, Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution, Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity, Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.
引用
收藏
页码:539 / 547
页数:17
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