Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models

被引：71
作者：
Klinker, Matthew W. [1 ]
Wei, Cheng-Hong [1 ]
机构：
[1] US FDA, Gene Transfer & Immunogen Branch, Div Cellular & Gene Therapies, Off Cellular Tissue & Gene Therapies,Ctr Biol Eva, 10903 New Hampshire Ave,Bldg 52-72,Room 3104, Silver Spring, MD 20993 USA
来源：
WORLD JOURNAL OF STEM CELLS | 2015年 / 7卷 / 03期
关键词：
Mesenchymal stromal cells; Mesenchymal stem cells; Autoimmunity; Animal models; Inflammation; Immunotherapy; VERSUS-HOST-DISEASE; COLLAGEN-INDUCED ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; STROMAL CELLS; BONE-MARROW; MULTIPLE-SCLEROSIS; IMMUNE-RESPONSE; ADIPOSE-TISSUE; MRL/LPR MICE; MOUSE MODEL;
D O I：
10.4252/wjsc.v7.i3.556
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Multipotent mesenchymal stromal cells [also known as mesenchymal stem cells (MSCs)] are currently being studied as a cell-based treatment for inflammatory disorders. Experimental animal models of human immune-mediated diseases have been instrumental in establishing their immunosuppressive properties. In this review, we summarize recent studies examining the effectiveness of MSCs as immunotherapy in several widely-studied animal models, including type 1 diabetes, experimental autoimmune arthritis, experimental autoimmune encephalomyelitis, inflammatory bowel disease, graft-vs - host disease, and systemic lupus erythematosus. In addition, we discuss mechanisms identified by which MSCs mediate immune suppression in specific disease models, and potential sources of functional variability of MSCs between studies.
引用
收藏
页码：556 / 567
页数：12
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