Memory, Mood, and Vitamin D in Persons with Parkinson's Disease

被引:67
作者
Peterson, Amie L. [1 ,5 ]
Murchison, Charles [5 ]
Zabetian, Cyrus [2 ,3 ,6 ]
Leverenz, James B. [2 ,3 ,4 ,6 ]
Watson, G. Stennis [3 ,6 ]
Montine, Thomas [6 ]
Carney, Natasha [1 ]
Bowman, Gene L. [5 ]
Edwards, Karen [6 ]
Quinn, Joseph F. [1 ,5 ]
机构
[1] Portland VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr PADRECC, Portland, OR USA
[2] VA Puget Sound Hlth Care Syst, Parkinsons Dis Res Educ & Clin Ctr PADRECC, Seattle, WA USA
[3] VA Puget Sound Hlth Care Syst, Geriat Res Educ & Clin Ctr GRECC, Seattle, WA USA
[4] VA Puget Sound Hlth Care Syst, MIRECC, Seattle, WA USA
[5] Oregon Hlth & Sci Univ, Portland, OR USA
[6] Univ Washington, Seattle, WA 98195 USA
基金
美国国家卫生研究院;
关键词
Parkinson's disease; vitamin D; dementia; depression; cognition; MILD COGNITIVE IMPAIRMENT; SERUM 25-HYDROXYVITAMIN D; D SUPPLEMENTATION; DOUBLE-BLIND; DEPRESSION; PREVALENCE; DEMENTIA; ASSOCIATION; VALIDITY;
D O I
10.3233/JPD-130206
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Research in recent years has suggested a role of vitamin D in the central nervous system. The final converting enzyme and the vitamin D receptor are found throughout the human brain. From animal studies vitamin D appears important in neurodevelopment, up-regulation of neurotrophic factors, stabilization of mitochondrial function, and antioxidation. Objective: To examine the relationship between serum vitamin D and neuropsychiatric function in persons with Parkinson's disease (PD). Methods: This is an add-on study to a longitudinal study following neuropsychiatric function in persons with PD. Baseline neuropsychiatric performance and serum 25-hydroxyvitamin D were examined for 286 participants with PD. Measures of global cognitive function (MMSE, MOCA, Mattis Dementia Scale), verbal memory (Hopkins Verbal Learning Test), fluency (animals, vegetables, and FAS words), visuospatial function (Benton Line Orientation), executive function (Trails Making Test and Digit-Symbol Substitution), PD severity (Hoehn & Yahr and Unified Parkinson's Disease Rating Scale) and depression (Geriatric Depression Scale (GDS)) were administered. Multivariate linear regression assessed the association between vitaminD concentration and neuropsychiatric function, in the entire cohort as well as the non-demented and demented subsets. Results: Using a multivariate model, higher vitamin D concentrations were associated with better performance on numerous neuropsychiatric tests in the non-demented subset of the cohort. Significant associations were specifically found between vitamin D concentration and verbal fluency and verbal memory (t = 4.31, p < 0.001 and t = 3.04, p = 0.0083). Vitamin D concentrations also correlated with depression scores (t=-3.08, p = 0.0083) in the non-demented subset. Conclusions: Higher plasma vitamin D is associated with better cognition and better mood in this sample of PD patients without dementia. Determination of causation will require a vitamin D intervention study.
引用
收藏
页码:547 / 555
页数:9
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