Is there a role for mesenchymal stem cells in autoimmune diseases?

被引：32

作者：

Uccelli, Antonio ^{[1
,2
]}

Mancardi, Gianluigi ^{[1
]}

Chiesa, Sabrina ^{[1
,2
]}

机构：

[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16132 Genoa, Italy

[2] Adv Biotechnol Ctr, I-16132 Genoa, Italy

来源：

AUTOIMMUNITY | 2008年 / 41卷 / 08期

关键词：

Mesenchymal stem cell; bone marrow; autoimmune diseases; multiple sclerosis; experimental autoimmune encephalomyelitis;

D O I：

10.1080/08916930802200166

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent reports have highlighted that adult stem cells are granted with yet poorly understood properties other than multipotentiality. In particular, mesenchymal stem cells (MSCs) represent a subset of adult stromal cells that can down-regulate several functions of the immune cells. In addition, MSCs may promote survival of damaged cells and tissues through paracrine mechanisms, possibly under the guidance of environmental cues. Thus, MSCs clinical application in autoimmune diseases seems an appealing opportunity and preclinical results in different experimental models of autoimmunity further support this strategy. Despite the absolute need for caution related to several clinical and technical issues, MSCs are now on the edge of a new era of clinical applications.

引用

页码：592 / 595

页数：4

共 27 条

[1] Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis [J].

Augello, Andrea ;

Tasso, Roberta ;

Negrini, Simone Maria ;

Cancedda, Ranieri ;

Pennesi, Giuseppina .

ARTHRITIS AND RHEUMATISM, 2007, 56 (04) :1175-1186

[2] Marrow stromal stem cells [J].

Bianco, P ;

Robey, PG .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (12) :1663-1668

[3] Adult mesenchymal stem cells for tissue engineering versus regenerative medicine [J].

Caplan, Arnold I. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (02) :341-347

[4] A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells [J].

Chabannes, Dominique ;

Hill, Marcelo ;

Merieau, Emmanuel ;

Rossignol, Julien ;

Brion, Regis ;

Soulillou, Jean Paul ;

Anegon, Ignacio ;

Cuturi, Maria Cristina .

BLOOD, 2007, 110 (10) :3691-3694

[5] Human mesenchymal stem cells modulate B-cell functions [J].

Corcione, A ;

Benvenuto, F ;

Ferretti, E ;

Giunti, D ;

Cappiello, V ;

Cazzanti, F ;

Risso, M ;

Gualandi, F ;

Mancardi, GL ;

Pistoia, V ;

Uccelli, A .

BLOOD, 2006, 107 (01) :367-372

[6] Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement [J].

Dominici, M. ;

Le Blanc, K. ;

Mueller, I. ;

Slaper-Cortenbach, I. ;

Marini, F. C. ;

Krause, D. S. ;

Deans, R. J. ;

Keating, A. ;

Prockop, D. J. ;

Horwitz, E. M. .

CYTOTHERAPY, 2006, 8 (04) :315-317

[7] Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis [J].

Gerdoni, Ezio ;

Gallo, Barbara ;

Casazza, Simona ;

Musio, Silvia ;

Bonanni, Ivan ;

Pedemonte, Enrico ;

Mantegazza, Renato ;

Frassoni, Francesco ;

Mancardi, Gianluigi ;

Pedotti, Rosetta ;

Uccelli, Antonio .

ANNALS OF NEUROLOGY, 2007, 61 (03) :219-227

[8] Bone marrow mesenchymal stem cefls induce division arrest anergy of activated T cells [J].

Glennie, S ;

Soeiro, I ;

Dyson, PJ ;

Lam, EWF ;

Dazzi, F .

BLOOD, 2005, 105 (07) :2821-2827

[9] Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells [J].

Le Blanc, K ;

Rasmusson, I ;

Sundberg, B ;

Götherström, C ;

Hassan, M ;

Uzunel, M ;

Ringdén, O .

LANCET, 2004, 363 (9419) :1439-1441

[10] Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation [J].

Meisel, R ;

Zibert, A ;

Laryea, M ;

Göbel, U ;

Däubener, W ;

Dilloo, D .

BLOOD, 2004, 103 (12) :4619-4621

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