A Review of Clinical and Preclinical Studies on Therapeutic Strategies Using Interleukin-12 in Cancer Therapy and the Protective Role of Interleukin-12 in Hematological Recovery in Chemoradiotherapy

被引：7

作者：

Li, Ping ^{[1
]}

Zhang, Hong ^{[1
]}

Ji, Lina ^{[1
]}

Wang, Zhi ^{[1
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Dept Pharm, Qingdao, Shandong, Peoples R China

来源：

MEDICAL SCIENCE MONITOR | 2020年 / 26卷

关键词：

Hematologic Neoplasms; Interleukin-12; Neoplasms; Second Primary; RECOMBINANT HUMAN INTERLEUKIN-12; HEMATOPOIETIC SUPPRESSION; INTERFERON-GAMMA; IL-12; CELLS; COMBINATION; RADIATION; RADIOTHERAPY; EXPRESSION; EXPANSION;

D O I：

10.12659/MSM.923855

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interleukin-12 (IL-12), a heterodimeric glycoprotein with alpha and beta subunits covalently bonded with a disulfide bond, is a potent anticancer agent. Its action is accomplished through a linkage of the adaptive and innate immune responses. IL-12 can promote the recovery of the hematopoietic system after cancer chemoradiotherapy by stimulating the physiological processes of stem cells, including cell proliferation and differentiation, reconstitution of hematopoietic function, and peripheral blood count recovery. We review therapeutic strategies using IL-12 in clinical studies, including single-agent and combination strategies in hematological tumors and solid tumors, and studies on the protective effects of IL-12 in chemoradiotherapy. This review highlights promising therapeutic strategies based on the anticancer role of IL-12 and the potential protective effects of IL-12 for cancer patients receiving chemoradiotherapy.

引用

页数：5

共 40 条

[21]

2-N

[22]

Guo N, 2017, WORLD J CLIN ONCOL, V8, P158, DOI 10.5306/wjco.v8.i2.158

[23] The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE [J].

Hagberg, Niklas ;

Joelsson, Martin ;

Leonard, Dag ;

Reid, Sarah ;

Eloranta, Maija-Leena ;

Mo, John ;

Nilsson, Magnus K. ;

Syvanen, Ann-Christine ;

Bryceson, Yenan T. ;

Ronnblom, Lars .

ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (07) :1070-1077

[24] In vivo Antitumor Effect of an HPV-specific Promoter driving IL-12 Expression in an HPV 16-positive Murine Model of Cervical Cancer [J].

Hugo Bermudez-Morales, Victor ;

Fierros-Zarate, Geny ;

Garcia-Melendrez, Celina ;

Manuel Alcocer-Gonzalez, Juan ;

Morales-Ortega, Ausencio ;

Peralta-Zaragoza, Oscar ;

Torres-Poveda, Kirvis ;

Isabel Burguete-Garcia, Ana ;

Hernandez-Marquez, Eva ;

Madrid-Marina, Vicente .

JOURNAL OF CANCER, 2016, 7 (14) :1950-1959

[25] THE FLT3 LIGAND POTENTLY AND DIRECTLY STIMULATES THE GROWTH AND EXPANSION OF PRIMITIVE MURINE BONE-MARROW PROGENITOR CELLS IN-VITRO - SYNERGISTIC INTERACTIONS WITH INTERLEUKIN (IL)-11, IL-12, AND OTHER HEMATOPOIETIC GROWTH-FACTORS [J].

JACOBSEN, SEW ;

OKKENHAUG, C ;

MYKLEBUST, J ;

VEIBY, OP ;

LYMAN, SD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (04) :1357-1363

[26] Interleukin 12: still a promising candidate for tumor immunotherapy? [J].

Lasek, Witold ;

Zagozdzon, Radoslaw ;

Jakobisiak, Marek .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2014, 63 (05) :419-435

[27] Dual-target IL-12-containing nanoparticles enhance T cell functions for cancer immunotherapy [J].

Li, Jieyu ;

Lin, Wansong ;

Chen, Huijing ;

Xu, Zhiping ;

Ye, Yunbin ;

Chen, Mingshui .

CELLULAR IMMUNOLOGY, 2020, 349

[28] P-MAPA and Interleukin-12 Reduce Cell Migration/Invasion and Attenuate the Toll-Like Receptor-Mediated Inflammatory Response in Ovarian Cancer SKOV-3 Cells: A Preliminary Study [J].

Lupi, Luiz Antonio ;

Delella, Flavia Karina ;

Cucielo, Maira Smaniotto ;

Romagnoli, Graziela Gorete ;

Kaneno, Ramon ;

Nunes, Iseu da Silva ;

Domeniconi, Raquel Fantin ;

Martinez, Marcelo ;

Martinez, Francisco Eduardo ;

Favaro, Wagner Josa ;

de Almeida Chuffa, Luiz Gustavo .

MOLECULES, 2020, 25 (01)

[29] FAS ANTIGEN EXPRESSION ON CD34(+) HUMAN MARROW-CELLS IS INDUCED BY INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR-ALPHA AND POTENTIATES CYTOKINE-MEDIATED HEMATOPOIETIC SUPPRESSION IN-VITRO [J].

MACIEJEWSKI, J ;

SELLERI, C ;

ANDERSON, S ;

YOUNG, NS .

BLOOD, 1995, 85 (11) :3183-3190

[30] Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment [J].

Mills, Bradley N. ;

Connolly, Kelli A. ;

Ye, Jian ;

Murphy, Joseph D. ;

Uccello, Taylor P. ;

Han, Booyeon J. ;

Zhao, Tony ;

Drage, Michael G. ;

Murthy, Aditi ;

Qiu, Haoming ;

Patel, Ankit ;

Figueroa, Nathania M. ;

Johnston, Carl J. ;

Prieto, Peter A. ;

Egilmez, Nejat K. ;

Belt, Brian A. ;

Lord, Edith M. ;

Linehan, David C. ;

Gerber, Scott A. .

CELL REPORTS, 2019, 29 (02) :406-+

← 1 2 3 4 →