Association of interleukin-18 and systemic lupus erythematosus

被引：16

作者：

Xu, Wang-Dong ^{[1
]}

Pan, Hai-Feng ^{[1
]}

Ye, Dong-Qing ^{[1
]}

机构：

[1] Anhui Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China

来源：

RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Interleukin-18; Systemic lupus erythematosus; Therapeutic; NATURAL-KILLER-CELLS; PROMOTER POLYMORPHISMS; DENDRITIC CELLS; IL-18; NEPHRITIS; DISEASE; SERUM; ACTIVATION; MICE;

D O I：

10.1007/s00296-012-2623-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-18 (IL-18), belongs to the IL-1 cytokine family, has a variety of effects on dendritic cell, T cell, natural killer cell. Previous studies have identified that IL-18 was associated with the pathogenesis of systemic lupus erythematosus (SLE), wherein elevated expression of IL-18 was found in the serum of patients, and IL-18 polymorphisms with susceptibility to SLE were reported, suggesting that IL-18 may be therapeutically relevant to SLE. In this article, we will discuss the role of IL-18 in the pathogenesis of and its therapeutic potential in SLE based on current understandings.

引用

页码：3055 / 3057

页数：3

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