Optoacoustic characterization of breast conserving surgery specimens - A pilot study

被引:10
作者
Balasundaram, Ghayathri [1 ]
Goh, Yonggeng [2 ]
Moothanchery, Mohesh [1 ]
Attia, Amalina [1 ]
Lim, Hann Qian [1 ]
Burton, Neal C. [3 ]
Qiu, Yi [3 ]
Putti, Thomas Choudary [4 ]
Chan, Ching Wan [5 ]
Hartmann, Mikael [5 ]
Quek, Swee Tian [2 ]
Olivo, Malini [1 ]
机构
[1] Singapore Bioimaging Consortium, Lab Bioopt Imaging, Singapore, Singapore
[2] Natl Univ Singapore Hosp, Dept Diagnost Imaging, Singapore, Singapore
[3] iThera Med GmbH, Munich, Germany
[4] Natl Univ Singapore Hosp, Dept Pathol, Singapore, Singapore
[5] Natl Univ Singapore Hosp, Dept Breast Surg, Singapore, Singapore
来源
PHOTOACOUSTICS | 2020年 / 19卷
基金
英国医学研究理事会;
关键词
Optoacoustic tomography; Breast-conserving surgery; Resection margin; Ultrasound; ONCOLOGY CONSENSUS GUIDELINE; FROZEN-SECTION ANALYSIS; AMERICAN SOCIETY; CANCER PATIENTS; TOMOGRAPHY; LUMPECTOMY; MARGINS; CONSERVATION; IRRADIATION; CARCINOMA;
D O I
10.1016/j.pacs.2020.100164
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
In this pilot study, we tested an ultrasound-guided optoacoustic tomography (US-OT) two-dimensional (2D) array scanner to understand the optoacoustic patterns of excised breastconserving surgery (BCS) specimens. We imaged 14 BCS specimens containing malignant tumors at eight wavelengths spanning 700 -1100 nm. Spectral unmixing across multiple wavelengths allowed for visualizing major intrinsic chromophores in the breast tissue including hemoglobin and lipid up to a depth of 7 mm. We identified less/no lipid signals within the tumor and intense deoxy-hemoglobin (Hb) signals on the rim of the tumor as unique characteristics of malignant tumors in comparison to no tumor region. We also observed continuous broad lipid signals as features of negative margins and compromised lipid signals interrupted by vasculature as features of positive margins. These differentiating patterns can form the basis of US-OT to be explored as an alternate, fast and efficient intraoperative method for evaluation of tumor resection margins.
引用
收藏
页数:9
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