G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

被引：205
作者：
Carvalho, Josue [1 ]
Mergny, Jean-Louis [2 ,3 ]
Salgado, Gilmar F. [2 ]
Queiroz, Joao A. [1 ]
Cruz, Carla [1 ]
机构：
[1] Univ Beira Interior, CICS UBI Ctr Invest Ciencias Saude, Ave Infante D Henrique, P-6200506 Covilha, Portugal
[2] Univ Bordeaux, ARNA Lab, INSERM, U1212,CNRS,UMR 5320,IECB, F-33600 Pessac, France
[3] Czech Acad Sci, Inst Biophys, Kralovopolska 135, Brno 61265, Czech Republic
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 09期
关键词：
DNA; TELOMERASE; AS1411; VISUALIZATION; INSTABILITY; SENSITIVITY; DERIVATIVES; MOLECULES; APTAMER; MOTIFS;
D O I：
10.1016/j.molmed.2020.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools ('friends', as healing anticancer drugs) and targets ('foes', within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.
引用
收藏
页码：848 / 861
页数：14
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