Glutamate receptors at atomic resolution

被引：225
作者：
Mayer, ML [1 ]
机构：
[1] Porter Neurosci Res Ctr, Bethesda, MD 20892 USA
来源：
NATURE | 2006年 / 440卷 / 7083期
关键词：
D O I：
10.1038/nature04709
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
At synapses throughout the brain and spinal cord, the amino-acid glutamate is the major excitatory neurotransmitter. During evolution, a family of glutamate-receptor ion channels seems to have been assembled from a kit consisting of discrete ligand-binding, ion-channel, modulatory and cytoplasmic domains. Crystallographic studies that exploit this unique architecture have greatly aided structural analysis of the ligand-binding core, but the results also pose a formidable challenge, namely that of resolving the allosteric mechanisms by which individual domains communicate and function in an intact receptor.
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收藏
页码：456 / 462
页数：7
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