Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model

被引：37

作者：

Moss, John A. ^{[1
]}

Malone, Amanda M. ^{[2
]}

Smith, Thomas J. ^{[1
,2
]}

Kennedy, Sean ^{[1
]}

Nguyen, Cali ^{[1
,2
]}

Vincent, Kathleen L. ^{[3
]}

Motamedi, Massoud ^{[3
]}

Baum, Marc M. ^{[1
]}

机构：

[1] Oak Crest Inst Sci, Dept Chem, Pasadena, CA USA

[2] Auritec Pharmaceut Inc, Santa Monica, CA USA

[3] Univ Texas Med Branch Galveston, Ctr Biomed Engn, Galveston, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 08期

关键词：

CONTRACEPTIVE VAGINAL RING; UNINTENDED PREGNANCIES; TENOFOVIR; PROPHYLAXIS; PREVENTION; HIV-1; EFFICACY; SAFETY;

D O I：

10.1128/AAC.00547-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

引用

收藏

页码：3994 / 3997

页数：4

相关论文

共 24 条

[1]

Balzarini J, 2007, LANCET, V369, P787, DOI 10.1016/S0140-6736(07)60202-5

[2] An intravaginal ring for the simultaneous delivery of multiple drugs [J].

Baum, Marc M. ;

Butkyavichene, Irina ;

Gilman, Joshua ;

Kennedy, Sean ;

Kopin, Etana ;

Malone, Amanda M. ;

Cali Nguyen ;

Smith, Thomas J. ;

Friend, David R. ;

Clark, Meredith R. ;

Moss, John A. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 101 (08) :2833-2843

[3] Contraceptive vaginal rings: a review [J].

Brache, Vivian ;

Faundes, Anibal .

CONTRACEPTION, 2010, 82 (05) :418-427

[4] Drug delivery in multiple indication (multipurpose) prevention technologies: systems to prevent HIV-1 transmission and unintended pregnancies or HSV-2 transmission [J].

Friend, David R. .

EXPERT OPINION ON DRUG DELIVERY, 2012, 9 (04) :417-427

[5] Combining prevention of HIV-1, other sexually transmitted infections and unintended pregnancies: Development of dual-protection technologies [J].

Friend, David R. ;

Doncel, Gustavo F. .

ANTIVIRAL RESEARCH, 2010, 88 :S47-S54

[6] Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir [J].

Garcia-Lerma, J. Gerardo ;

Otten, Ron A. ;

Qari, Shoukat H. ;

Jackson, Eddie ;

Cong, Mian-er ;

Masciotra, Silvina ;

Luo, Wei ;

Kim, Caryn ;

Adams, Debra R. ;

Monsour, Michael ;

Lipscomb, Jonathan ;

Johnson, Jeffrey A. ;

Delinsky, David ;

Schinazi, Raymond F. ;

Janssen, Robert ;

Folks, Thomas M. ;

Heneine, Walid .

PLOS MEDICINE, 2008, 5 (02) :291-299

[7]

Gilead Sciences Inc., 2012, PROD MON PR VIR TEN

[8] Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women [J].

Karim, Quarraisha Abdool ;

Karim, Salim S. Abdool ;

Frohlich, Janet A. ;

Grobler, Anneke C. ;

Baxter, Cheryl ;

Mansoor, Leila E. ;

Kharsany, Ayesha B. M. ;

Sibeko, Sengeziwe ;

Mlisana, Koleka P. ;

Omar, Zaheen ;

Gengiah, Tanuja N. ;

Maarschalk, Silvia ;

Arulappan, Natasha ;

Mlotshwa, Mukelisiwe ;

Morris, Lynn ;

Taylor, Douglas .

SCIENCE, 2010, 329 (5996) :1168-1174

[9] Antiretroviral prophylaxis: a defining moment in HIV control [J].

Karim, Salim S. Abdool ;

Karim, Quarraisha Abdool .

LANCET, 2011, 378 (9809) :E23-E25

[10] Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women [J].

Karim, Salim S. Abdool ;

Kashuba, Angela D. M. ;

Werner, Lise ;

Karim, Quarraisha Abdool .

LANCET, 2011, 378 (9787) :279-281