Synovitis and bone inflammation in early rheumatoid arthritis: high-resolution multi-pinhole SPECT versus MRI

被引：17

作者：

Buchbender, Christian ^{[1
]}

Ostendorf, Benedikt ^{[2
]}

Mattes-Gyoergy, Katalin ^{[1
]}

Miese, Falk

Wittsack, Hans-Joerg ^{[1
]}

Quentin, Michael ^{[1
]}

Specker, Christof ^{[3
]}

Schneider, Matthias ^{[2
]}

Antoch, Gerald ^{[1
]}

Mueller, Hans-Wilhelm

Scherer, Axel ^{[1
]}

机构：

[1] Univ Dusseldorf, Fac Med, Dept Diagnost & Intervent Radiol, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Fac Med, Dept Rheumatol, D-40225 Dusseldorf, Germany

[3] Kliniken Essen Sued, Dept Rheumatol & Clin Immunol, Essen, Germany

来源：

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY | 2013年 / 19卷 / 01期

关键词：

EMISSION COMPUTED-TOMOGRAPHY; FINGER JOINTS; PATHOGENESIS; DISEASE; EDEMA;

D O I：

10.4261/1305-3825.DIR.5922-12.1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

PURPOSE We aimed to assess the relationship between bone inflammation in multi-pinhole single-photon emission computed tomography (MPH-SPEC) and synovitis detected by magnetic resonance imaging (MRI) in early rheumatoid arthritis patients. MATERIALS AND METHODS MPH-SPECT with technetium dicarboxypropanedisphosphonate (Tc-99mDPD) and 3 Tesla MRI were performed in 10 early rheumatoid arthritis patients. Eight finder joint sites were assessed for increased osteoblastic activity using visual and region-of-interest (ROI) analysis Presence of joint inflaimmation in MRI was investigated using the subscores of the rheumatoid arthritis MRI score. RESULTS Tc-99mDPD uptake was increased in 38 (47.5%) and 22 (27.5%) joint sites as determined by visual and ROI analysis, respectively. A total of 32 (84.2%) sites with increased bone metabolism showed a normal MRI bone signal. The MPH-SPECT uptake ratio was elevated only in the subgroup with severe synovitis (P < 0.001). CONCLUSION In early rheumatoid arthritis, molecular imaging with MPH-SPECT detects higher rates of inflammatory bone involvement compared to MRI. Our preliminary data-suggest that osteitis is related to severe synovitis.

引用

页码：20 / 24

页数：5

共 18 条

[1] 2010 Rheumatoid Arthritis Classification Criteria An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative [J].

Aletaha, Daniel ;

Neogi, Tuhina ;

Silman, Alan J. ;

Funovits, Julia ;

Felson, David T. ;

Bingham, Clifton O., III ;

Birnbaum, Neal S. ;

Burmester, Gerd R. ;

Bykerk, Vivian P. ;

Cohen, Marc D. ;

Combe, Bernard ;

Costenbader, Karen H. ;

Dougados, Maxime ;

Emery, Paul ;

Ferraccioli, Gianfranco ;

Hazes, Johanna M. W. ;

Hobbs, Kathryn ;

Huizinga, Tom W. J. ;

Kavanaugh, Arthur ;

Kay, Jonathan ;

Kvien, Tore K. ;

Laing, Timothy ;

Mease, Philip ;

Menard, Henri A. ;

Moreland, Larry W. ;

Naden, Raymond L. ;

Pincus, Theodore ;

Smolen, Josef S. ;

Stanislawska-Biernat, Ewa ;

Symmons, Deborah ;

Tak, Paul P. ;

Upchurch, Katherine S. ;

Vencovsky, Jiri ;

Wolfe, Frederick ;

Hawker, Gillian .

ARTHRITIS AND RHEUMATISM, 2010, 62 (09) :2569-2581

[2] Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease [J].

Dalbeth, N. ;

Smith, T. ;

Gray, S. ;

Doyle, A. ;

Antill, P. ;

Lobo, M. ;

Robinson, E. ;

King, A. ;

Cornish, J. ;

Shalley, G. ;

Gao, A. ;

McQueen, F. M. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (02) :279-282

[3] Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques [J].

Gotthardt, Martin ;

Bleeker-Rovers, Chantal P. ;

Boerman, Otto C. ;

Oyen, Wim J. G. .

JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (12) :1937-1949

[4]

Gravallese EM, 1998, AM J PATHOL, V152, P943

[5] Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis [J].

Jimenez-Boj, E ;

Redlich, K ;

Türk, B ;

Hanslik-Schnabel, B ;

Wanivenhaus, A ;

Chott, A ;

Smolen, JS ;

Schett, G .

JOURNAL OF IMMUNOLOGY, 2005, 175 (04) :2579-2588

[6] What is MRI bone oedema in rheumatoid arthritis and why does it matter? [J].

McQueen, Fiona M. ;

Ostendorf, Benedikt .

ARTHRITIS RESEARCH & THERAPY, 2006, 8 (06)

[7] High-resolution multipinhole single-photon-emission computed tomography in experimental and human arthritis [J].

Ostendorf, B ;

Scherer, A ;

Wirrwar, A ;

Hoppin, JW ;

Lackas, C ;

Schramm, NU ;

Cohnen, M ;

Mödder, U ;

van den Berg, WB ;

Müller, HW ;

Schneider, M ;

Joosten, LAB .

ARTHRITIS AND RHEUMATISM, 2006, 54 (04) :1096-1104

[8] Early detection of bony alterations in rheumatoid and erosive arthritis of finger joints with high-resolution single photon emission computed tomography, and differentiation between them [J].

Ostendorf, B. ;

Mattes-Gyoergy, K. ;

Reichelt, D. C. ;

Blondin, D. ;

Wirrwar, A. ;

Lanzman, R. ;

Mueller, H. W. ;

Schneider, M. ;

Moedder, U. ;

Scherer, A. .

SKELETAL RADIOLOGY, 2010, 39 (01) :55-61

[9] High-resolution SPECT imaging of bony pathology in early arthritis of finger joints [J].

Ostendorf, Benedikt ;

Wirrwar, Andreas ;

Mattes-Gyoergy, Katalin ;

Iking-Konert, Christof ;

Blondin, Dirk ;

Moedder, Ulrich ;

Mueller, Hans-Wilhelm ;

Schneider, Matthias ;

Scherer, Axel .

RHEUMATOLOGY, 2009, 48 (07) :853-854

[10] The role of single photon emission computed tomography in bone imaging [J].

Sarikaya, I ;

Sarikaya, A ;

Holder, LE .

SEMINARS IN NUCLEAR MEDICINE, 2001, 31 (01) :3-16

← 1 2 →