Cytotoxic effects of hyperatomarin, a prenylated phloroglucinol from Hypericum annulatum Moris subsp annulatum, in a panel of malignant cell tines

被引：18

作者：

Momekov, G. ^{[1
]}

Ferdinandov, D. ^{[1
,2
]}

Zheleva-Dimitrova, D. ^{[3
]}

Nedialkov, P. ^{[3
]}

Girreser, U. ^{[4
]}

Kitanov, G. ^{[3
]}

机构：

[1] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria

[2] Med Univ Sofia, St Ivan Rilski Univ Hosp, Dept Neurosurg, Sofia 1000, Bulgaria

[3] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria

[4] Univ Kiel, Inst Pharm, Kiel, Germany

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 11期

关键词：

Hyperatomarin; Prenylated phloroglucinols; Cytotoxicity; Apoptosis;

D O I：

10.1016/j.phymed.2008.04.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The cytotoxic effects of hyperatomarin - a prenylated phloroglucinol isolated from Hypericum annulatum Moris subsp. annulatum were assessed in a broad spectrum of tumor cell lines originating from leukemias, lymphomas and solid malignancies. The tested compound exerted strong concentration-dependent cytotoxic effects (IC50 values ranging 0.14-15.7 mu M), comparable to and even outclassing in some cell lines those of the established anti-cancer drug daunorubicin. Exposure of different human tumor cell lines to hyperatomarin resulted in strong mono- and oligonucleosomal fragmentation of genomic DNA, as evidenced by 'Cell death detection' ELISA kit and by DNA-electrophoresis, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：1010 / 1015

页数：6

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