Efficient synthesis of benzothiophenes by [4+1] cycloaddition of 2-mercaptobenzaldehyde derivatives with isocyanides

被引：3

作者：

Soeta, Takahiro ^{[1
]}

Shitaya, Saori ^{[1
]}

Okuno, Takumi ^{[1
]}

Fujinami, Shuhei ^{[1
]}

Ukaji, Yutaka ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Mat Sci, Kanazawa, Ishikawa 9201192, Japan

来源：

TETRAHEDRON | 2016年 / 72卷 / 49期

基金：

日本学术振兴会;

关键词：

Isocyanide; 4+1] Cycloaddition; 2-Mercaptobenzaldehyde; Benzothiophene derivative; INHIBITORS; ZILEUTON; IMINES;

D O I：

10.1016/j.tet.2016.09.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a [4+1] cycloaddition reaction of isocyanides with 2-mercaptobenzaldehydes and/or their disulfide derivatives, promoted by LiI.2H(2)O, to afford benzothiophene derivatives in moderate to good yields. Isocyanides, 2-mercaptobenzaldehydes and disulfide derivatives of various types were used successfully in the reaction. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：7901 / 7905

页数：5

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