Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome

被引:31
|
作者
Kyriakidis, Ioannis [1 ,2 ]
Papa, Anna [1 ]
机构
[1] Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol 1, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Expt Pharmacol Lab, Sch Med, Thessaloniki 54124, Greece
关键词
Hemorrhagic fever with renal syndrome; Dobrava-Belgrade hantavirus; Cytokines; Greece; PUUMALA HANTAVIRUS INFECTION; NECROSIS-FACTOR-ALPHA; VIRUS NUCLEOCAPSID PROTEIN; C-REACTIVE PROTEIN; INTERLEUKIN-6; CYTOKINES; EXPRESSION; SEVERITY; DISEASE;
D O I
10.1016/j.virusres.2013.03.020
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
It is generally accepted that the pathogenesis of hantavirus infections is the result of virus-mediated host immune response. Hantaviruses, and mainly Dobrava-Belgrade virus, are present in Greece, and cause to humans hemorrhagic fever with renal syndrome (HFRS). Serum IL-6, IL-8, IL-10, TNF-alpha and sTNFR1 levels were measured in 29 HFRS Greek patients. Significant higher sTNFR1, IL-6, IL-8 and IL-10 levels were observed in severe than in mild/moderate cases, while TNF-alpha did not seem to be associated with disease severity. Correlations between cytokine levels and their fluctuation over time after onset of the illness, along with comparisons from previously published data on the field, led in building an immune response pattern for HFRS. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:91 / 94
页数:4
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