Titin and nebulin content in human skeletal muscle following eccentric resistance exercise

被引：40
作者：
Trappe, TA [1 ]
Carrithers, JA
White, F
Lambert, CP
Evans, WJ
Dennis, RA
机构：
[1] Univ Arkansas Med Sci, Dept Geriatr, Donald W Reynolds Ctr Aging, Nutr Metab & Exercise Lab, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Physiol & Biophys, Little Rock, AR 72205 USA
[3] Cent Arkansas Vet Hlth Care Syst, Little Rock, AR USA
来源：
MUSCLE & NERVE | 2002年 / 25卷 / 02期
关键词：
contractile proteins; myofibril; muscle damage; nebulin; proteolysis; titin;
D O I：
10.1002/mus.10037
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We measured titin and nebulin content in muscle biopsies from the vastus lateralis before and 24 h after one bout of high-intensity eccentric knee extensor resistance exercise in seven men (26 +/- 3 years). Titin and nebulin content were significantly (P < 0.05) reduced after exercise by 30 and 15%, respectively. These results suggest that the structural components of the myofibrillar apparatus are degraded following high-intensity eccentric resistance exercise in humans. Loss of these proteins may have important implications for the mechanisms regulating the adaptive response of skeletal muscle to resistance exercise. (C) 2002 John Wiley Sons, Inc.
引用
收藏
页码：289 / 292
页数：4
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