Impact of scanning density on spectral domain optical coherence tomography assessments in neovascular age-related macular degeneration

被引:20
作者
Baranano, Anne E. [1 ]
Keane, Pearse A. [1 ,2 ,3 ]
Ruiz-Garcia, Humberto [1 ]
Walsh, Alexander C. [1 ]
Sadda, Srinivas R. [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Doheny Eye Inst, Doheny Image Reading Ctr, Los Angeles, CA 90033 USA
[2] Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr Ophthalmol, London, England
[3] UCL Inst Ophthalmol, London, England
关键词
age-related macular degeneration; choroidal neovascularization; optical coherence Tomography; scanning density; spectral domain; vascular endothelial growth factor; QUANTITATIVE SUBANALYSIS; RANIBIZUMAB; REPRODUCIBILITY;
D O I
10.1111/j.1755-3768.2012.02398.x
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To determine the effect of optical coherence tomography (OCT) B-scan density on the qualitative assessment of neovascular age-related macular degeneration (AMD). Methods: Data were collected from 59 patients imaged with Topcon 3D OCT-1000 (128 B-scans x 512 A-scans). Custom software was used to generate less dense subsets of scans: 1/16 (eight B-scans), 1/8 (16 B-scans), 1/4 (32 B-scans) and 1/2 (64 B-scans). At each B-scan density, scans were assessed for cystoid spaces, subretinal fluid (SRF), subretinal tissue (SRT) and pigment epithelium detachment (PED). For each sampling density, sensitivity, specificity and predictive values were calculated using the full volume scan (128 B-scans) as the reference standard. Results: For cystoid spaces, the detection sensitivity was 76.3% at 1/16 density; this rose to 89.5% with a 1/4 density. For SRF, the detection sensitivity was 75.0% at a 1/16 density; this increased to 91.1% with 1/4 density. For PED, even at the lowest sampling density (1/16) the detection sensitivity was 86.4%; this rose to 94.9% at 1/4 density. For SRT, detection sensitivity at a 1/16 density was 64.7% and only rose above 90% with the densest sampling subset (1/2). Conclusions: Use of scanning protocols with reduced sampling densities resulted in decreased detection of key features of neovascular AMD; despite this, a sampling density reduced to 1/4 appeared to allow accurate assessment for most features. Current management of neovascular AMD is dependent on qualitative assessment of OCT images; with the recent proliferation of OCT systems, optimization and standardization of scanning protocols may be of value.
引用
收藏
页码:E274 / E280
页数:7
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