Anti-inflammatory effects of tea-flavonoids

被引：16

作者：

Hoensch, H. ^{[1
]}

Oertel, R. ^{[2
]}

机构：

[1] Marienhosp Darmstadt, D-64285 Darmstadt, Germany

[2] Tech Univ Dresden, Fak Med, Klin Pharmakol Abt, Dresden, Germany

来源：

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2012年 / 137卷 / 51-52期

关键词：

flavonoids; anti-inflammation; green tea; chronic inflammatory reaction; cytokine; chemokines; inflammatory bowel disease; GREEN TEA; PROSPECTIVE COHORT; BLOOD-PRESSURE; CONSUMPTION; POLYPHENOLS; MECHANISMS; CANCER; RISK;

D O I：

10.1055/s-0032-1327348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tea flavonoids belong to the large group of polyphenols and display antioxidative, anti-inflammatory and anti-neoplastic activities. These phytochemicals are xenobiotics and are synthesized by tea plants such as Camellia sinensis and Camomilla recucita. These botanicals exhibit in vivo activities similar to that of biologicals which are widely used for chronic inflammatory diseases (rheumatoid arthritis, chronic inflammatory bowel disease). Epigallocathechin gallate and apigenin from these plants inhibit cytokines, chemokines and activated immune cells in vivo and in vitro. Clinical disorders with induced inflammatory pathways could benefit from flavonoid treatment. Dietary supplementation with specific tea-flavonoids could be used for Crohn's disease, ulcerative colitis and irritable bowel syndrome. Suppression of cytokine production could ultimately lead to inhibition of carcinogenesis. This mechanism could explain why flavonoids are effective in the prevention of intestinal neoplasia. This innovative new form of therapy should be tested in controlled, randomized clinical studies.© Georg Thieme Verlag KG · Stuttgart.

引用

页码：2738 / 2740

页数：3

共 22 条

[11] Emerging role of bioflavonoids in gastroenterology: Especially their effects on intestinal neoplasia [J].